Cell-impermeable staurosporine analog targets extracellular kinases to inhibit HSV and SARS-CoV-2

Herpes simplex virus (HSV) receptor engagement activates phospholipid scramblase triggering Akt translocation to the outer leaflet of the plasma membrane where its subsequent phosphorylation promotes viral entry. We hypothesize that this previously unrecognized outside-inside signaling pathway is em...

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Detalles Bibliográficos
Autores principales: Cheshenko, Natalia, Bonanno, Jeffrey B., Hoffmann, Hans-Heinrich, Jangra, Rohit K., Chandran, Kartik, Rice, Charles M., Almo, Steven C., Herold, Betsy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569420/
https://www.ncbi.nlm.nih.gov/pubmed/36245045
http://dx.doi.org/10.1038/s42003-022-04067-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569420/
https://www.ncbi.nlm.nih.gov/pubmed/36245045
http://dx.doi.org/10.1038/s42003-022-04067-4

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