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Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects

Background: Increased cholesterol absorption and reduced synthesis are processes that have been associated with cardiovascular disease risk in a controversial way. However, most of the studies involving markers of cholesterol synthesis and absorption include conditions, such as obesity, diabetes, dy...

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Autores principales: Nunes, Valéria Sutti, de Campos, Edite Vieira Silva, Baracat, Jamal, França, Victor, Gomes, Érica Ivana Lázaro, Coelho, Raissa Peres, Nakandakare, Edna Regina, Zago, Vanessa Helena Souza, de Faria, Eliana Cotta, Quintão, Eder Carlos Rocha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569444/
https://www.ncbi.nlm.nih.gov/pubmed/36233298
http://dx.doi.org/10.3390/ijms231911997
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author Nunes, Valéria Sutti
de Campos, Edite Vieira Silva
Baracat, Jamal
França, Victor
Gomes, Érica Ivana Lázaro
Coelho, Raissa Peres
Nakandakare, Edna Regina
Zago, Vanessa Helena Souza
de Faria, Eliana Cotta
Quintão, Eder Carlos Rocha
author_facet Nunes, Valéria Sutti
de Campos, Edite Vieira Silva
Baracat, Jamal
França, Victor
Gomes, Érica Ivana Lázaro
Coelho, Raissa Peres
Nakandakare, Edna Regina
Zago, Vanessa Helena Souza
de Faria, Eliana Cotta
Quintão, Eder Carlos Rocha
author_sort Nunes, Valéria Sutti
collection PubMed
description Background: Increased cholesterol absorption and reduced synthesis are processes that have been associated with cardiovascular disease risk in a controversial way. However, most of the studies involving markers of cholesterol synthesis and absorption include conditions, such as obesity, diabetes, dyslipidemia, which can be confounding factors. The present study aimed at investigating the relationships of plasma cholesterol synthesis and absorption markers with cardiovascular disease (CVD) risk factors, cIMT (carotid intima-media thickness), and the presence of carotid plaques in asymptomatic subjects. Methods: A cross-sectional study was carried out in 270 asymptomatic individuals and anthropometrical parameters, fasting plasma lipids, glucometabolic profiles, high-sensitivity C-reactive protein (hs-CRP), markers of cholesterol synthesis (desmosterol and lathosterol), absorption (campesterol and sitosterol), cIMT, and the presence of atherosclerotic plaques were analyzed. Results: Among the selected subjects aged between 19 and 75 years, 51% were females. Age, body mass index, systolic and diastolic blood pressure, total cholesterol, non-HDL-C, triglycerides, glucose, and lathosterol/sitosterol ratios correlated positively with cIMT (p ≤ 0.05). Atherosclerotic plaques were present in 19% of the subjects. A direct association of carotid plaques with campesterol, OR = 1.71 (95% CI = 1.04–2.82, p ≤ 0.05) and inverse associations with both ratios lathosterol/campesterol, OR = 0.29 (CI = 0.11–0.80, p ≤ 0.05) and lathosterol/sitosterol, OR = 0.45 (CI = 0.22–0.95, p ≤ 0.05) were observed in univariate logistic regression analysis. Conclusions: The findings suggested that campesterol may be associated with atherosclerotic plaques and the lathosterol/campesterol or sitosterol ratios suggested an inverse association. Furthermore, synthesis and absorption of cholesterol are inverse processes, and the absorption marker, campesterol, may reflect changes in body cholesterol homeostasis with atherogenic potential.
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spelling pubmed-95694442022-10-17 Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects Nunes, Valéria Sutti de Campos, Edite Vieira Silva Baracat, Jamal França, Victor Gomes, Érica Ivana Lázaro Coelho, Raissa Peres Nakandakare, Edna Regina Zago, Vanessa Helena Souza de Faria, Eliana Cotta Quintão, Eder Carlos Rocha Int J Mol Sci Article Background: Increased cholesterol absorption and reduced synthesis are processes that have been associated with cardiovascular disease risk in a controversial way. However, most of the studies involving markers of cholesterol synthesis and absorption include conditions, such as obesity, diabetes, dyslipidemia, which can be confounding factors. The present study aimed at investigating the relationships of plasma cholesterol synthesis and absorption markers with cardiovascular disease (CVD) risk factors, cIMT (carotid intima-media thickness), and the presence of carotid plaques in asymptomatic subjects. Methods: A cross-sectional study was carried out in 270 asymptomatic individuals and anthropometrical parameters, fasting plasma lipids, glucometabolic profiles, high-sensitivity C-reactive protein (hs-CRP), markers of cholesterol synthesis (desmosterol and lathosterol), absorption (campesterol and sitosterol), cIMT, and the presence of atherosclerotic plaques were analyzed. Results: Among the selected subjects aged between 19 and 75 years, 51% were females. Age, body mass index, systolic and diastolic blood pressure, total cholesterol, non-HDL-C, triglycerides, glucose, and lathosterol/sitosterol ratios correlated positively with cIMT (p ≤ 0.05). Atherosclerotic plaques were present in 19% of the subjects. A direct association of carotid plaques with campesterol, OR = 1.71 (95% CI = 1.04–2.82, p ≤ 0.05) and inverse associations with both ratios lathosterol/campesterol, OR = 0.29 (CI = 0.11–0.80, p ≤ 0.05) and lathosterol/sitosterol, OR = 0.45 (CI = 0.22–0.95, p ≤ 0.05) were observed in univariate logistic regression analysis. Conclusions: The findings suggested that campesterol may be associated with atherosclerotic plaques and the lathosterol/campesterol or sitosterol ratios suggested an inverse association. Furthermore, synthesis and absorption of cholesterol are inverse processes, and the absorption marker, campesterol, may reflect changes in body cholesterol homeostasis with atherogenic potential. MDPI 2022-10-09 /pmc/articles/PMC9569444/ /pubmed/36233298 http://dx.doi.org/10.3390/ijms231911997 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nunes, Valéria Sutti
de Campos, Edite Vieira Silva
Baracat, Jamal
França, Victor
Gomes, Érica Ivana Lázaro
Coelho, Raissa Peres
Nakandakare, Edna Regina
Zago, Vanessa Helena Souza
de Faria, Eliana Cotta
Quintão, Eder Carlos Rocha
Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
title Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
title_full Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
title_fullStr Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
title_full_unstemmed Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
title_short Plasma Campesterol Is Positively Associated with Carotid Plaques in Asymptomatic Subjects
title_sort plasma campesterol is positively associated with carotid plaques in asymptomatic subjects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569444/
https://www.ncbi.nlm.nih.gov/pubmed/36233298
http://dx.doi.org/10.3390/ijms231911997
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