Cargando…

Novel In Vivo CometChip Reveals NDMA-Induced DNA Damage and Repair in Multiple Mouse Tissues

The comet assay is a versatile assay for detecting DNA damage in eukaryotic cells. The assay can measure the levels of various types of damage, including DNA strand breaks, abasic sites and alkali-sensitive sites. Furthermore, the assay can also be modified to include purified DNA glycosylases so th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Owiti, Norah A., Corrigan, Joshua J., Pribyl, Lee J., Kay, Jennifer E., Engelward, Bevin P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569458/ https://www.ncbi.nlm.nih.gov/pubmed/36233095 http://dx.doi.org/10.3390/ijms231911776

Ejemplares similares

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates
por: Ngo, Le P, et al.
Publicado: (2020)

High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology
por: Watson, Christa, et al.
Publicado: (2014)

CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells
por: Ge, Jing, et al.
Publicado: (2014)

Using the HepaCometChip Assay for Broad‐Spectrum DNA Damage Analysis
por: Owiti, Norah A., et al.
Publicado: (2022)

A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures
por: Buick, Julie K., et al.
Publicado: (2021)

Implications of an epidemiological study showing an association between in utero NDMA exposure and childhood cancer
por: Engelward, Bevin P.
Publicado: (2021)

The High-Throughput In Vitro CometChip Assay for the Analysis of Metal Oxide Nanomaterial Induced DNA Damage
por: Boyadzhiev, Andrey, et al.
Publicado: (2022)

Reduced DNA Repair Capacity in Prostate Cancer Patients: A Phenotypic Approach Using the CometChip
por: Ortiz-Sánchez, Carmen, et al.
Publicado: (2022)

Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip(®) assay in TK6 cells
por: Buick, Julie K., et al.
Publicado: (2022)

MalariaCometChip for high-throughput quantification of DNA damage in Plasmodium falciparum
por: Xiong, Aoli, et al.
Publicado: (2021)

Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
por: Wang, Yiying, et al.
Publicado: (2021)

A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage
por: Li, Jianfeng, et al.
Publicado: (2022)

Skin Immuno-CometChip in 3D vs. 2D Cultures to Screen Topical Toxins and Skin-Specific Cytochrome Inducers
por: Rosenthal, Dean S., et al.
Publicado: (2023)

DNA Damage after Continuous Irradiation: Yanch and Engelward Respond
por: Yanch, Jacquelyn, et al.
Publicado: (2012)

Is this the end for ranitidine? NDMA presence continues to confound
por: Wagner, Jennifer A., et al.
Publicado: (2021)

Inflammation-Induced Cell Proliferation Potentiates DNA Damage-Induced Mutations In Vivo
por: Kiraly, Orsolya, et al.
Publicado: (2015)

The Occurrence of N-nitrosodimethylamine (NDMA) in Swimming Pools: An Overview
por: Mustapha, Saheed, et al.
Publicado: (2021)

O21 - The role of DNA damage and repair in allergic airway inflammation
por: Chan, Tze Khee, et al.
Publicado: (2014)

The Effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 Expression in Human Neutrophils
por: Jablonski, Jakub, et al.
Publicado: (2011)

N-nitrosodimethylamine (NDMA) contamination of ranitidine products: A review of recent findings
por: Aldawsari, Fahad S., et al.
Publicado: (2021)

Association between ranitidine use with potential NDMA impurities and risk of cancer in Korea
por: Joung, Kyung-In, et al.
Publicado: (2022)

Detection of DNA damage by alkaline comet assay in mouse colonic mucosa
por: Boutet-Robinet, Elisa, et al.
Publicado: (2021)

The Comet Assay in Drosophila: A Tool to Study Interactions between DNA Repair Systems in DNA Damage Responses In Vivo and Ex Vivo
por: Rodríguez, Rubén, et al.
Publicado: (2023)

Oxidation of Citalopram with Sodium Hypochlorite and Chlorine Dioxide: Influencing Factors and NDMA Formation Kinetics
por: Lv, Juan, et al.
Publicado: (2019)

Radiation Dose-Rate: Engelward and Yanch Respond
por: Engelward, Bevin, et al.
Publicado: (2012)

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest
por: Rai, Prashant, et al.
Publicado: (2016)

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair
por: Xiong, Aoli, et al.
Publicado: (2020)

Open Access to Research Is in the Public Interest
por: Engelward, Bevin P, et al.
Publicado: (2007)

ndmaSNF: cancer subtype discovery based on integrative framework assisted by network diffusion model
por: Yang, Chao, et al.
Publicado: (2017)

In Vitro Analysis of N-Nitrosodimethylamine (NDMA) Formation From Ranitidine Under Simulated Gastrointestinal Conditions
por: Gao, Zongming, et al.
Publicado: (2021)

Comet assay measures of DNA damage as biomarkers of irinotecan response in colorectal cancer in vitro and in vivo
por: Wood, Joanna P, et al.
Publicado: (2015)

Use of N-nitrosodimethylamine (NDMA) contaminated valsartan products and risk of cancer: Danish nationwide cohort study
por: Pottegård, Anton, et al.
Publicado: (2018)

Effect of cryopreservation on DNA damage and DNA repair activity in human blood samples in the comet assay
por: Bankoglu, Ezgi Eyluel, et al.
Publicado: (2021)

HiComet: a high-throughput comet analysis tool for large-scale DNA damage assessment
por: Lee, Taehoon, et al.
Publicado: (2018)

Formation Mechanism of NDMA from Ranitidine, Trimethylamine, and Other Tertiary Amines during Chloramination: A Computational Study
por: Liu, Yong Dong, et al.
Publicado: (2014)

Radiation-induced DNA damage and repair in human γδ and αβ T-lymphocytes analysed by the alkaline comet assay
por: Lisowska, Halina, et al.
Publicado: (2010)

The in vivo genotoxicity of isotretinoin assessed by comet assay
por: Bordbar, Maede, et al.
Publicado: (2020)

Correction to: HiComet: a high-throughput comet analysis tool for large-scale DNA damage assessment
por: Lee, Taehoon, et al.
Publicado: (2018)

B-Comet Assay (Comet Assay on Buccal Cells) for the Evaluation of Primary DNA Damage in Human Biomonitoring Studies
por: Russo, Carla, et al.
Publicado: (2020)

Cell survival after DNA damage in the comet assay
por: Bankoglu, Ezgi Eyluel, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0bf6iuov6qmeehqqg2j701vevd