Characterization of Two Mouse Chd7 Heterozygous Loss-of-Function Models Shows Dysgenesis of the Corpus Callosum and Previously Unreported Features of CHARGE Syndrome

CHARGE syndrome is a rare congenital disorder frequently caused by mutations in the chromodomain helicase DNA-binding protein-7 CHD7. Here, we developed and systematically characterized two genetic mouse models with identical, heterozygous loss-of-function mutation of the Chd7 gene engineered on inb...

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Detalles Bibliográficos
Autores principales: Collins, Stephan C., Vancollie, Valerie E., Mikhaleva, Anna, Wagner, Christel, Balz, Rebecca, Lelliott, Christopher J., Yalcin, Binnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569499/
https://www.ncbi.nlm.nih.gov/pubmed/36232804
http://dx.doi.org/10.3390/ijms231911509

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