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Biologically Active Diterpenoids in the Clerodendrum Genus—A Review

One of the key areas of interest in pharmacognosy is that of the diterpenoids; many studies have been performed to identify new sources, their optimal isolation and biological properties. An important source of abietane-, pimarane-, clerodane-type diterpenoids and their derivatives are the members o...

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Detalles Bibliográficos
Autores principales: Kuźma, Łukasz, Gomulski, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569547/
https://www.ncbi.nlm.nih.gov/pubmed/36232298
http://dx.doi.org/10.3390/ijms231911001
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author Kuźma, Łukasz
Gomulski, Jan
author_facet Kuźma, Łukasz
Gomulski, Jan
author_sort Kuźma, Łukasz
collection PubMed
description One of the key areas of interest in pharmacognosy is that of the diterpenoids; many studies have been performed to identify new sources, their optimal isolation and biological properties. An important source of abietane-, pimarane-, clerodane-type diterpenoids and their derivatives are the members of the genus Clerodendrum, of the Lamiaceae. Due to their diverse chemical nature, and the type of plant material, a range of extraction techniques are needed with various temperatures, solvent types and extraction times, as well as the use of an ultrasound bath. The diterpenoids isolated from Clerodendrum demonstrate a range of cytotoxic, anti-proliferative, antibacterial, anti-parasitic and anti-inflammatory activities. This review describes the various biological activities of the diterpenoids isolated so far from species of Clerodendrum with the indication of the most active ones, as well as those from other plant sources, taking into account their structure in terms of their activity, and summarises the methods for their extraction.
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spelling pubmed-95695472022-10-17 Biologically Active Diterpenoids in the Clerodendrum Genus—A Review Kuźma, Łukasz Gomulski, Jan Int J Mol Sci Review One of the key areas of interest in pharmacognosy is that of the diterpenoids; many studies have been performed to identify new sources, their optimal isolation and biological properties. An important source of abietane-, pimarane-, clerodane-type diterpenoids and their derivatives are the members of the genus Clerodendrum, of the Lamiaceae. Due to their diverse chemical nature, and the type of plant material, a range of extraction techniques are needed with various temperatures, solvent types and extraction times, as well as the use of an ultrasound bath. The diterpenoids isolated from Clerodendrum demonstrate a range of cytotoxic, anti-proliferative, antibacterial, anti-parasitic and anti-inflammatory activities. This review describes the various biological activities of the diterpenoids isolated so far from species of Clerodendrum with the indication of the most active ones, as well as those from other plant sources, taking into account their structure in terms of their activity, and summarises the methods for their extraction. MDPI 2022-09-20 /pmc/articles/PMC9569547/ /pubmed/36232298 http://dx.doi.org/10.3390/ijms231911001 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuźma, Łukasz
Gomulski, Jan
Biologically Active Diterpenoids in the Clerodendrum Genus—A Review
title Biologically Active Diterpenoids in the Clerodendrum Genus—A Review
title_full Biologically Active Diterpenoids in the Clerodendrum Genus—A Review
title_fullStr Biologically Active Diterpenoids in the Clerodendrum Genus—A Review
title_full_unstemmed Biologically Active Diterpenoids in the Clerodendrum Genus—A Review
title_short Biologically Active Diterpenoids in the Clerodendrum Genus—A Review
title_sort biologically active diterpenoids in the clerodendrum genus—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569547/
https://www.ncbi.nlm.nih.gov/pubmed/36232298
http://dx.doi.org/10.3390/ijms231911001
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