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Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study

The association between 25-hydroxyvitamin D and 5-, 10-, or 15-year weight change were assessed in a population-based, prospective study conducted in Lausanne, Switzerland. Data from the first (2009–2012, N = 3527, 51.3% women), second (2014–2017, N = 3237, 53.8% women), and third (2018–2021, N = 25...

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Autores principales: Patriota, Pollyanna, Rezzi, Serge, Guessous, Idris, Marques-Vidal, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569579/
https://www.ncbi.nlm.nih.gov/pubmed/36232402
http://dx.doi.org/10.3390/ijms231911100
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author Patriota, Pollyanna
Rezzi, Serge
Guessous, Idris
Marques-Vidal, Pedro
author_facet Patriota, Pollyanna
Rezzi, Serge
Guessous, Idris
Marques-Vidal, Pedro
author_sort Patriota, Pollyanna
collection PubMed
description The association between 25-hydroxyvitamin D and 5-, 10-, or 15-year weight change were assessed in a population-based, prospective study conducted in Lausanne, Switzerland. Data from the first (2009–2012, N = 3527, 51.3% women), second (2014–2017, N = 3237, 53.8% women), and third (2018–2021, N = 2567, 54.2% women) follow-ups were used. A weighted genetic risk score (GRS) of 115 SNPs associated with vitamin D levels was constructed. At baseline, the GRS correlated positively with 25-hydroxyvitamin D levels based on a Spearman rank correlation and 95% confidence interval: 0.198 (0.166; 0.231), p < 0.001; and with body mass index: 0.036 (0.004; 0.068), p = 0.028. No association was found between quartiles of GRS and weight changes at 5, 10, or 15 years: multivariate-adjusted weight changes ± SEM at 5-years follow-up were 1.39 ± 0.17, 1.13 ± 0.17, 1.24 ± 0.17, and 1.00 ± 0.17 kg for the first to the fourth quartile of the GRS, respectively (p = 0.401). Two-step linear regression showed a significant but clinically meaningless association between GRS-derived vitamin D and weight change at 5- and 15-years: slope and 95% confidence interval for a 5 nmol/L increase in GRS-derived 25-hydroxyvitamin D levels: 0.082 (0.013; 0.150) and 0.130 (0.018; 0.243) kg, respectively. We conclude that there is little association between genetically determined 25-hydroxyvitamin D levels and weight gain.
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spelling pubmed-95695792022-10-17 Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study Patriota, Pollyanna Rezzi, Serge Guessous, Idris Marques-Vidal, Pedro Int J Mol Sci Article The association between 25-hydroxyvitamin D and 5-, 10-, or 15-year weight change were assessed in a population-based, prospective study conducted in Lausanne, Switzerland. Data from the first (2009–2012, N = 3527, 51.3% women), second (2014–2017, N = 3237, 53.8% women), and third (2018–2021, N = 2567, 54.2% women) follow-ups were used. A weighted genetic risk score (GRS) of 115 SNPs associated with vitamin D levels was constructed. At baseline, the GRS correlated positively with 25-hydroxyvitamin D levels based on a Spearman rank correlation and 95% confidence interval: 0.198 (0.166; 0.231), p < 0.001; and with body mass index: 0.036 (0.004; 0.068), p = 0.028. No association was found between quartiles of GRS and weight changes at 5, 10, or 15 years: multivariate-adjusted weight changes ± SEM at 5-years follow-up were 1.39 ± 0.17, 1.13 ± 0.17, 1.24 ± 0.17, and 1.00 ± 0.17 kg for the first to the fourth quartile of the GRS, respectively (p = 0.401). Two-step linear regression showed a significant but clinically meaningless association between GRS-derived vitamin D and weight change at 5- and 15-years: slope and 95% confidence interval for a 5 nmol/L increase in GRS-derived 25-hydroxyvitamin D levels: 0.082 (0.013; 0.150) and 0.130 (0.018; 0.243) kg, respectively. We conclude that there is little association between genetically determined 25-hydroxyvitamin D levels and weight gain. MDPI 2022-09-21 /pmc/articles/PMC9569579/ /pubmed/36232402 http://dx.doi.org/10.3390/ijms231911100 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Patriota, Pollyanna
Rezzi, Serge
Guessous, Idris
Marques-Vidal, Pedro
Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study
title Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study
title_full Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study
title_fullStr Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study
title_full_unstemmed Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study
title_short Vitamin D and Weight Change: A Mendelian Randomization, Prospective Study
title_sort vitamin d and weight change: a mendelian randomization, prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569579/
https://www.ncbi.nlm.nih.gov/pubmed/36232402
http://dx.doi.org/10.3390/ijms231911100
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