Cargando…

High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations

The crucial role of integrin in pathological processes such as tumor progression and metastasis formation has inspired intense efforts to design novel pharmaceutical agents modulating integrin functions in order to provide new tools for potential therapies. In the past decade, we have investigated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Acconcia, Clementina, Paladino, Antonella, Valle, Maria della, Farina, Biancamaria, Del Gatto, Annarita, Gaetano, Sonia Di, Capasso, Domenica, Gentile, Maria Teresa, Malgieri, Gaetano, Isernia, Carla, Saviano, Michele, Fattorusso, Roberto, Zaccaro, Laura, Russo, Luigi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569650/ https://www.ncbi.nlm.nih.gov/pubmed/36232339 http://dx.doi.org/10.3390/ijms231911039

Ejemplares similares

Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide
por: Capasso, Domenica, et al.
Publicado: (2020)

RGDechi-hCit: αvβ3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells
por: Capasso, Domenica, et al.
Publicado: (2014)

Evaluation of the anti-angiogenic properties of the new selective α(V)β(3 )integrin antagonist RGDechiHCit
por: Santulli, Gaetano, et al.
Publicado: (2011)

Probing the Residual Structure in Avian Prion Hexarepeats by CD, NMR and MD Techniques
por: Russo, Luigi, et al.
Publicado: (2013)

A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
por: Pirone, Luciano, et al.
Publicado: (2020)

Substitution of the Native Zn(II) with Cd(II), Co(II) and Ni(II) Changes the Downhill Unfolding Mechanism of Ros87 to a Completely Different Scenario
por: Grazioso, Rinaldo, et al.
Publicado: (2020)

γ sulphate PNA (PNA S): Highly Selective DNA Binding Molecule Showing Promising Antigene Activity
por: Avitabile, Concetta, et al.
Publicado: (2012)

An Overview of Peptide-Based Molecules as Potential Drug Candidates for Multiple Sclerosis
por: Del Gatto, Annarita, et al.
Publicado: (2021)

Inclusions of Pesticides by β-Cyclodextrin in Solution and Solid State: Chlorpropham, Monuron, and Propanil
por: Dragone, Martina, et al.
Publicado: (2023)

NMR Structure and Dynamics of the Resuscitation Promoting Factor RpfC Catalytic Domain
por: Maione, Vincenzo, et al.
Publicado: (2015)

Copper (I) or (II) Replacement of the Structural Zinc Ion in the Prokaryotic Zinc Finger Ros Does Not Result in a Functional Domain
por: Dragone, Martina, et al.
Publicado: (2022)

Polystyrene nanoplastics affect the human ubiquitin structure and ubiquitination in cells: a high-resolution study
por: della Valle, M., et al.
Publicado: (2022)

Co(II) Coordination in Prokaryotic Zinc Finger Domains as Revealed by UV-Vis Spectroscopy
por: Sivo, Valeria, et al.
Publicado: (2017)

Structural Insight of the Full-Length Ros Protein: A Prototype of the Prokaryotic Zinc-Finger Family
por: D’Abrosca, Gianluca, et al.
Publicado: (2020)

Therapeutic Potential of a Novel α(v)β(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type
por: Hill, Billy Samuel, et al.
Publicado: (2019)

Alpha- and Beta-Cyclodextrin Inclusion Complexes with 5-Fluorouracil: Characterization and Cytotoxic Activity Evaluation
por: Di Donato, Cristina, et al.
Publicado: (2016)

Peptoids: Smart and Emerging Candidates for the Diagnosis of Cancer, Neurological and Autoimmune Disorders
por: Giorgio, Anna, et al.
Publicado: (2023)

The change of conditions does not affect Ros87 downhill folding mechanism
por: Grazioso, Rinaldo, et al.
Publicado: (2020)

Structural characterization of the thermal unfolding pathway of human VEGFR1 D2 domain
por: Diana, Donatella, et al.
Publicado: (2021)

The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism
por: Persico, Marco, et al.
Publicado: (2017)

Structural Characterization of the Lactobacillus Plantarum FlmC Protein Involved in Biofilm Formation
por: D’Abrosca, Gianluca, et al.
Publicado: (2018)

Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein
por: Russo, Luigi, et al.
Publicado: (2022)

Host and Viral Zinc-Finger Proteins in COVID-19
por: Esposito, Sabrina, et al.
Publicado: (2022)

MucR binds multiple target sites in the promoter of its own gene and is a heat‐stable protein: Is MucR a H‐NS‐like protein?
por: Baglivo, Ilaria, et al.
Publicado: (2018)

Characterization of Complexes between Imidacloprid and β-Cyclodextrin: Evaluation of the Toxic Activity in Algae and Rotifers
por: Lavorgna, Margherita, et al.
Publicado: (2023)

Physicochemical Characterization and Cytotoxic Activity Evaluation of Hydroxymethylferrocene:β-Cyclodextrin Inclusion Complex
por: Iacovino, Rosa, et al.
Publicado: (2012)

Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir
por: Di Donato, Cristina, et al.
Publicado: (2020)

More Is Always Better Than One: The N-Terminal Domain of the Spike Protein as Another Emerging Target for Hampering the SARS-CoV-2 Attachment to Host Cells
por: Di Gaetano, Sonia, et al.
Publicado: (2021)

Identifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation
por: Pirone, Luciano, et al.
Publicado: (2018)

Conformational Ensembles by NMR and MD Simulations in Model Heptapeptides with Select Tri-Peptide Motifs
por: Krishnan, V. V., et al.
Publicado: (2021)

Editorial: Peptidomimetics: Synthetic Tools for Drug Discovery and Development
por: Del Gatto, Annarita, et al.
Publicado: (2021)

β-Cyclodextrin Inclusion Complex to Improve Physicochemical Properties of Pipemidic Acid: Characterization and Bioactivity Evaluation
por: Iacovino, Rosa, et al.
Publicado: (2013)

Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments: A MD Simulation and NMR Study
por: Peng, Cheng, et al.
Publicado: (2019)

Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins
por: Malgieri, Gaetano, et al.
Publicado: (2018)

Design, Synthesis, and Anticancer Activity of a Selenium-Containing Galectin-3 and Galectin-9N Inhibitor
por: Di Gaetano, Sonia, et al.
Publicado: (2022)

Synergistic Applications of MD and NMR for the Study of Biological Systems
por: Fisette, Olivier, et al.
Publicado: (2012)

Cullin3 - BTB Interface: A Novel Target for Stapled Peptides
por: de Paola, Ivan, et al.
Publicado: (2015)

Structural and functional studies of Stf76 from the Sulfolobus islandicus plasmid–virus pSSVx: a novel peculiar member of the winged helix–turn–helix transcription factor family
por: Contursi, Patrizia, et al.
Publicado: (2014)

NMR and MD Analysis of the Bonding Interaction of Vancomycin with Muramyl Pentapeptide
por: Ślusarz, Rafał, et al.
Publicado: (2022)

Nanobody Paratope Ensembles in Solution Characterized by MD Simulations and NMR
por: Fernández-Quintero, Monica L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gddoqed87h8bju09jm0j4c3hf6