Cargando…

Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders

Advancements in medicine have increased the longevity of humans, resulting in a higher incidence of chronic diseases. Due to the rise in the elderly population, age-dependent neurodegenerative disorders are becoming increasingly prevalent. The available treatment options only provide symptomatic rel...

Descripción completa

Detalles Bibliográficos
Autores principales: Chaudhary, Sapana, Chaudhary, Sameer, Rawat, Sakshi, Kulkarni, Archana, Bilgrami, Anwar L., Perveen, Asma, Alghamdi, Badrah S., Zughaibi, Torki Al, Ashraf, Ghulam Md, Alam, Mohammad Zubair, Hussain, Tabish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569834/
https://www.ncbi.nlm.nih.gov/pubmed/36232314
http://dx.doi.org/10.3390/ijms231911012
_version_ 1784809953561673728
author Chaudhary, Sapana
Chaudhary, Sameer
Rawat, Sakshi
Kulkarni, Archana
Bilgrami, Anwar L.
Perveen, Asma
Alghamdi, Badrah S.
Zughaibi, Torki Al
Ashraf, Ghulam Md
Alam, Mohammad Zubair
Hussain, Tabish
author_facet Chaudhary, Sapana
Chaudhary, Sameer
Rawat, Sakshi
Kulkarni, Archana
Bilgrami, Anwar L.
Perveen, Asma
Alghamdi, Badrah S.
Zughaibi, Torki Al
Ashraf, Ghulam Md
Alam, Mohammad Zubair
Hussain, Tabish
author_sort Chaudhary, Sapana
collection PubMed
description Advancements in medicine have increased the longevity of humans, resulting in a higher incidence of chronic diseases. Due to the rise in the elderly population, age-dependent neurodegenerative disorders are becoming increasingly prevalent. The available treatment options only provide symptomatic relief and do not cure the underlying cause of the disease. Therefore, it has become imperative to discover new markers and therapies to modulate the course of disease progression and develop better treatment options for the affected individuals. Growing evidence indicates that neuroinflammation is a common factor and one of the main inducers of neuronal damage and degeneration. Galectins (Gals) are a class of β-galactoside-binding proteins (lectins) ubiquitously expressed in almost all vital organs. Gals modulate various cellular responses and regulate significant biological functions, including immune response, proliferation, differentiation, migration, and cell growth, through their interaction with glycoproteins and glycolipids. In recent years, extensive research has been conducted on the Gal superfamily, with Gal-1, Gal-3, and Gal-9 in prime focus. Their roles have been described in modulating neuroinflammation and neurodegenerative processes. In this review, we discuss the role of Gals in the causation and progression of neurodegenerative disorders. We describe the role of Gals in microglia and astrocyte modulation, along with their pro- and anti-inflammatory functions. In addition, we discuss the potential use of Gals as a novel therapeutic target for neuroinflammation and restoring tissue damage in neurodegenerative diseases.
format Online
Article
Text
id pubmed-9569834
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95698342022-10-17 Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders Chaudhary, Sapana Chaudhary, Sameer Rawat, Sakshi Kulkarni, Archana Bilgrami, Anwar L. Perveen, Asma Alghamdi, Badrah S. Zughaibi, Torki Al Ashraf, Ghulam Md Alam, Mohammad Zubair Hussain, Tabish Int J Mol Sci Review Advancements in medicine have increased the longevity of humans, resulting in a higher incidence of chronic diseases. Due to the rise in the elderly population, age-dependent neurodegenerative disorders are becoming increasingly prevalent. The available treatment options only provide symptomatic relief and do not cure the underlying cause of the disease. Therefore, it has become imperative to discover new markers and therapies to modulate the course of disease progression and develop better treatment options for the affected individuals. Growing evidence indicates that neuroinflammation is a common factor and one of the main inducers of neuronal damage and degeneration. Galectins (Gals) are a class of β-galactoside-binding proteins (lectins) ubiquitously expressed in almost all vital organs. Gals modulate various cellular responses and regulate significant biological functions, including immune response, proliferation, differentiation, migration, and cell growth, through their interaction with glycoproteins and glycolipids. In recent years, extensive research has been conducted on the Gal superfamily, with Gal-1, Gal-3, and Gal-9 in prime focus. Their roles have been described in modulating neuroinflammation and neurodegenerative processes. In this review, we discuss the role of Gals in the causation and progression of neurodegenerative disorders. We describe the role of Gals in microglia and astrocyte modulation, along with their pro- and anti-inflammatory functions. In addition, we discuss the potential use of Gals as a novel therapeutic target for neuroinflammation and restoring tissue damage in neurodegenerative diseases. MDPI 2022-09-20 /pmc/articles/PMC9569834/ /pubmed/36232314 http://dx.doi.org/10.3390/ijms231911012 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chaudhary, Sapana
Chaudhary, Sameer
Rawat, Sakshi
Kulkarni, Archana
Bilgrami, Anwar L.
Perveen, Asma
Alghamdi, Badrah S.
Zughaibi, Torki Al
Ashraf, Ghulam Md
Alam, Mohammad Zubair
Hussain, Tabish
Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders
title Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders
title_full Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders
title_fullStr Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders
title_full_unstemmed Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders
title_short Galectins—Potential Therapeutic Targets for Neurodegenerative Disorders
title_sort galectins—potential therapeutic targets for neurodegenerative disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569834/
https://www.ncbi.nlm.nih.gov/pubmed/36232314
http://dx.doi.org/10.3390/ijms231911012
work_keys_str_mv AT chaudharysapana galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT chaudharysameer galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT rawatsakshi galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT kulkarniarchana galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT bilgramianwarl galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT perveenasma galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT alghamdibadrahs galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT zughaibitorkial galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT ashrafghulammd galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT alammohammadzubair galectinspotentialtherapeutictargetsforneurodegenerativedisorders
AT hussaintabish galectinspotentialtherapeutictargetsforneurodegenerativedisorders