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A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease

Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabete...

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Detalles Bibliográficos
Autores principales: Čater, Maša, Hölter, Sabine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569835/
https://www.ncbi.nlm.nih.gov/pubmed/36232867
http://dx.doi.org/10.3390/ijms231911562
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author Čater, Maša
Hölter, Sabine M.
author_facet Čater, Maša
Hölter, Sabine M.
author_sort Čater, Maša
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description Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer’s disease. The relationship between diabetes and Alzheimer’s disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes.
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spelling pubmed-95698352022-10-17 A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease Čater, Maša Hölter, Sabine M. Int J Mol Sci Review Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer’s disease. The relationship between diabetes and Alzheimer’s disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes. MDPI 2022-09-30 /pmc/articles/PMC9569835/ /pubmed/36232867 http://dx.doi.org/10.3390/ijms231911562 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Čater, Maša
Hölter, Sabine M.
A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
title A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
title_full A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
title_fullStr A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
title_full_unstemmed A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
title_short A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
title_sort pathophysiological intersection of diabetes and alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569835/
https://www.ncbi.nlm.nih.gov/pubmed/36232867
http://dx.doi.org/10.3390/ijms231911562
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