Cargando…
A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease
Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabete...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569835/ https://www.ncbi.nlm.nih.gov/pubmed/36232867 http://dx.doi.org/10.3390/ijms231911562 |
_version_ | 1784809953803894784 |
---|---|
author | Čater, Maša Hölter, Sabine M. |
author_facet | Čater, Maša Hölter, Sabine M. |
author_sort | Čater, Maša |
collection | PubMed |
description | Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer’s disease. The relationship between diabetes and Alzheimer’s disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes. |
format | Online Article Text |
id | pubmed-9569835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95698352022-10-17 A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease Čater, Maša Hölter, Sabine M. Int J Mol Sci Review Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer’s disease. The relationship between diabetes and Alzheimer’s disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes. MDPI 2022-09-30 /pmc/articles/PMC9569835/ /pubmed/36232867 http://dx.doi.org/10.3390/ijms231911562 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Čater, Maša Hölter, Sabine M. A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease |
title | A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease |
title_full | A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease |
title_fullStr | A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease |
title_full_unstemmed | A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease |
title_short | A Pathophysiological Intersection of Diabetes and Alzheimer’s Disease |
title_sort | pathophysiological intersection of diabetes and alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569835/ https://www.ncbi.nlm.nih.gov/pubmed/36232867 http://dx.doi.org/10.3390/ijms231911562 |
work_keys_str_mv | AT catermasa apathophysiologicalintersectionofdiabetesandalzheimersdisease AT holtersabinem apathophysiologicalintersectionofdiabetesandalzheimersdisease AT catermasa pathophysiologicalintersectionofdiabetesandalzheimersdisease AT holtersabinem pathophysiologicalintersectionofdiabetesandalzheimersdisease |