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Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis
Lysyl oxidases have long been considered key secreted extracellular matrix modifying enzymes. As such, their activity has been associated with the crosslinking of collagens and elastin, and as a result, they have been linked to multiple developmental and pathological processes. However, numerous lin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569843/ https://www.ncbi.nlm.nih.gov/pubmed/36232685 http://dx.doi.org/10.3390/ijms231911378 |
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author | Zaffryar-Eilot, Shelly Hasson, Peleg |
author_facet | Zaffryar-Eilot, Shelly Hasson, Peleg |
author_sort | Zaffryar-Eilot, Shelly |
collection | PubMed |
description | Lysyl oxidases have long been considered key secreted extracellular matrix modifying enzymes. As such, their activity has been associated with the crosslinking of collagens and elastin, and as a result, they have been linked to multiple developmental and pathological processes. However, numerous lines of evidence also demonstrated that members of this enzyme family are localized and are active within the cytoplasm or cell nuclei, where they regulate and participate in distinct cellular events. In this review, we focus on a few of these events and highlight the intracellular role these enzymes play. Close examination of these events, suggest that the intracellular activities of lysyl oxidases is mostly observed in processes where concomitant changes in the extracellular matrix takes place. Here, we suggest that the LOX family members act in the relay between changes in the cells’ environment and the intracellular processes that promote them or that follow. |
format | Online Article Text |
id | pubmed-9569843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95698432022-10-17 Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis Zaffryar-Eilot, Shelly Hasson, Peleg Int J Mol Sci Review Lysyl oxidases have long been considered key secreted extracellular matrix modifying enzymes. As such, their activity has been associated with the crosslinking of collagens and elastin, and as a result, they have been linked to multiple developmental and pathological processes. However, numerous lines of evidence also demonstrated that members of this enzyme family are localized and are active within the cytoplasm or cell nuclei, where they regulate and participate in distinct cellular events. In this review, we focus on a few of these events and highlight the intracellular role these enzymes play. Close examination of these events, suggest that the intracellular activities of lysyl oxidases is mostly observed in processes where concomitant changes in the extracellular matrix takes place. Here, we suggest that the LOX family members act in the relay between changes in the cells’ environment and the intracellular processes that promote them or that follow. MDPI 2022-09-27 /pmc/articles/PMC9569843/ /pubmed/36232685 http://dx.doi.org/10.3390/ijms231911378 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zaffryar-Eilot, Shelly Hasson, Peleg Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis |
title | Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis |
title_full | Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis |
title_fullStr | Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis |
title_full_unstemmed | Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis |
title_short | Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis |
title_sort | lysyl oxidases: orchestrators of cellular behavior and ecm remodeling and homeostasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569843/ https://www.ncbi.nlm.nih.gov/pubmed/36232685 http://dx.doi.org/10.3390/ijms231911378 |
work_keys_str_mv | AT zaffryareilotshelly lysyloxidasesorchestratorsofcellularbehaviorandecmremodelingandhomeostasis AT hassonpeleg lysyloxidasesorchestratorsofcellularbehaviorandecmremodelingandhomeostasis |