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Enhancer RNA (eRNA) in Human Diseases
Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some st...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569849/ https://www.ncbi.nlm.nih.gov/pubmed/36232885 http://dx.doi.org/10.3390/ijms231911582 |
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author | Wang, Yunzhe Zhang, Chenyang Wang, Yuxiang Liu, Xiuping Zhang, Zhao |
author_facet | Wang, Yunzhe Zhang, Chenyang Wang, Yuxiang Liu, Xiuping Zhang, Zhao |
author_sort | Wang, Yunzhe |
collection | PubMed |
description | Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some studies also revealed the potential clinical utility of eRNAs in these diseases. In this review, we summarized the recent studies regarding the pathological mechanisms of eRNAs as well as their potential utility across human diseases, including cancers, neurodegenerative disorders, cardiovascular diseases and metabolic diseases. It could help us to understand how eRNAs are engaged in the processes of diseases and to obtain better insight of eRNAs in diagnosis, prognosis or therapy. The studies we reviewed here indicate the enormous therapeutic potency of eRNAs across human diseases. |
format | Online Article Text |
id | pubmed-9569849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95698492022-10-17 Enhancer RNA (eRNA) in Human Diseases Wang, Yunzhe Zhang, Chenyang Wang, Yuxiang Liu, Xiuping Zhang, Zhao Int J Mol Sci Review Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some studies also revealed the potential clinical utility of eRNAs in these diseases. In this review, we summarized the recent studies regarding the pathological mechanisms of eRNAs as well as their potential utility across human diseases, including cancers, neurodegenerative disorders, cardiovascular diseases and metabolic diseases. It could help us to understand how eRNAs are engaged in the processes of diseases and to obtain better insight of eRNAs in diagnosis, prognosis or therapy. The studies we reviewed here indicate the enormous therapeutic potency of eRNAs across human diseases. MDPI 2022-09-30 /pmc/articles/PMC9569849/ /pubmed/36232885 http://dx.doi.org/10.3390/ijms231911582 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Yunzhe Zhang, Chenyang Wang, Yuxiang Liu, Xiuping Zhang, Zhao Enhancer RNA (eRNA) in Human Diseases |
title | Enhancer RNA (eRNA) in Human Diseases |
title_full | Enhancer RNA (eRNA) in Human Diseases |
title_fullStr | Enhancer RNA (eRNA) in Human Diseases |
title_full_unstemmed | Enhancer RNA (eRNA) in Human Diseases |
title_short | Enhancer RNA (eRNA) in Human Diseases |
title_sort | enhancer rna (erna) in human diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569849/ https://www.ncbi.nlm.nih.gov/pubmed/36232885 http://dx.doi.org/10.3390/ijms231911582 |
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