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Enhancer RNA (eRNA) in Human Diseases

Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some st...

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Detalles Bibliográficos
Autores principales: Wang, Yunzhe, Zhang, Chenyang, Wang, Yuxiang, Liu, Xiuping, Zhang, Zhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569849/
https://www.ncbi.nlm.nih.gov/pubmed/36232885
http://dx.doi.org/10.3390/ijms231911582
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author Wang, Yunzhe
Zhang, Chenyang
Wang, Yuxiang
Liu, Xiuping
Zhang, Zhao
author_facet Wang, Yunzhe
Zhang, Chenyang
Wang, Yuxiang
Liu, Xiuping
Zhang, Zhao
author_sort Wang, Yunzhe
collection PubMed
description Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some studies also revealed the potential clinical utility of eRNAs in these diseases. In this review, we summarized the recent studies regarding the pathological mechanisms of eRNAs as well as their potential utility across human diseases, including cancers, neurodegenerative disorders, cardiovascular diseases and metabolic diseases. It could help us to understand how eRNAs are engaged in the processes of diseases and to obtain better insight of eRNAs in diagnosis, prognosis or therapy. The studies we reviewed here indicate the enormous therapeutic potency of eRNAs across human diseases.
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spelling pubmed-95698492022-10-17 Enhancer RNA (eRNA) in Human Diseases Wang, Yunzhe Zhang, Chenyang Wang, Yuxiang Liu, Xiuping Zhang, Zhao Int J Mol Sci Review Enhancer RNAs (eRNAs), a class of non-coding RNAs (ncRNAs) transcribed from enhancer regions, serve as a type of critical regulatory element in gene expression. There is increasing evidence demonstrating that the aberrant expression of eRNAs can be broadly detected in various human diseases. Some studies also revealed the potential clinical utility of eRNAs in these diseases. In this review, we summarized the recent studies regarding the pathological mechanisms of eRNAs as well as their potential utility across human diseases, including cancers, neurodegenerative disorders, cardiovascular diseases and metabolic diseases. It could help us to understand how eRNAs are engaged in the processes of diseases and to obtain better insight of eRNAs in diagnosis, prognosis or therapy. The studies we reviewed here indicate the enormous therapeutic potency of eRNAs across human diseases. MDPI 2022-09-30 /pmc/articles/PMC9569849/ /pubmed/36232885 http://dx.doi.org/10.3390/ijms231911582 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Yunzhe
Zhang, Chenyang
Wang, Yuxiang
Liu, Xiuping
Zhang, Zhao
Enhancer RNA (eRNA) in Human Diseases
title Enhancer RNA (eRNA) in Human Diseases
title_full Enhancer RNA (eRNA) in Human Diseases
title_fullStr Enhancer RNA (eRNA) in Human Diseases
title_full_unstemmed Enhancer RNA (eRNA) in Human Diseases
title_short Enhancer RNA (eRNA) in Human Diseases
title_sort enhancer rna (erna) in human diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569849/
https://www.ncbi.nlm.nih.gov/pubmed/36232885
http://dx.doi.org/10.3390/ijms231911582
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