A Single Oral Vitamin D(3) Bolus Reduces Inflammatory Markers in Healthy Saudi Males

Vitamin D deficiency has increased in the general population and is a public health issue. Vitamin D plays an important role in regulating the immune system, e.g., by modulating the production of inflammatory cytokines. In most countries, the recommended maximal daily dose of vitamin D(3) is 4000 IU (100 µg) per day. In this study, we investigated whether a single vitamin D(3) bolus can reduce the levels of the inflammatory markers interleukin (IL) 6, IL8 and tumor necrosis factor (TNF) within one month. Fifty healthy Saudi males were recruited from the local community in Jeddah city and were orally supplemented with a single dose of 80,000 IU vitamin D(3). Serum samples were collected at time points 0, 1 and 30 days, and serum levels of IL6, IL8 and TNF, parathyroid hormone (PTH), 25-hydroxyvitamin D(3) (25(OH)D(3)), triglycerides, cholesterol, calcium (Ca(2+)) and phosphate (PO(4−)) were determined. On average, the vitamin D(3) bolus resulted in a significant increase in vitamin D status as well as in a significant decrease in the levels of inflammatory cytokines even one month after supplementation without changing serum Ca(2+), PO(4−) or lipid levels. In conclusion, single high-dose vitamin D(3) supplementation is safe for reducing inflammation markers and may lead to an update of current recommendations for vitamin D intake, in order to prevent critical health problems.