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Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions

Early life stress (ELS) encompasses exposure to aversive experiences during early development, such as neglect or maltreatment. Animal and human studies indicate that ELS has maladaptive effects on brain development, leaving individuals more vulnerable to developing behavioral and neuropsychiatric d...

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Autores principales: Campbell, Taylor S., Donoghue, Katelyn M., Ghosh, Urmi, Nelson, Christina M., Roth, Tania L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569911/
https://www.ncbi.nlm.nih.gov/pubmed/36233029
http://dx.doi.org/10.3390/ijms231911729
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author Campbell, Taylor S.
Donoghue, Katelyn M.
Ghosh, Urmi
Nelson, Christina M.
Roth, Tania L.
author_facet Campbell, Taylor S.
Donoghue, Katelyn M.
Ghosh, Urmi
Nelson, Christina M.
Roth, Tania L.
author_sort Campbell, Taylor S.
collection PubMed
description Early life stress (ELS) encompasses exposure to aversive experiences during early development, such as neglect or maltreatment. Animal and human studies indicate that ELS has maladaptive effects on brain development, leaving individuals more vulnerable to developing behavioral and neuropsychiatric disorders later in life. This result occurs in part to disruptions in Brain derived neurotrophic factor (Bdnf) gene regulation, which plays a vital role in early neural programming and brain health in adulthood. A potential treatment mechanism to reverse the effects of ELS on Bdnf expression is aerobic exercise due to its neuroprotective properties and positive impact on Bdnf expression. Aerobic exercise opens the door to exciting and novel potential treatment strategies because it is a behavioral intervention readily and freely available to the public. In this review, we discuss the current literature investigating the use of exercise interventions in animal models of ELS to reverse or mitigate ELS-induced changes in Bdnf expression. We also encourage future studies to investigate sensitive periods of exercise exposure, as well as sufficient duration of exposure, on epigenetic and behavioral outcomes to help lead to standardized practices in the exercise intervention field.
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spelling pubmed-95699112022-10-17 Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions Campbell, Taylor S. Donoghue, Katelyn M. Ghosh, Urmi Nelson, Christina M. Roth, Tania L. Int J Mol Sci Review Early life stress (ELS) encompasses exposure to aversive experiences during early development, such as neglect or maltreatment. Animal and human studies indicate that ELS has maladaptive effects on brain development, leaving individuals more vulnerable to developing behavioral and neuropsychiatric disorders later in life. This result occurs in part to disruptions in Brain derived neurotrophic factor (Bdnf) gene regulation, which plays a vital role in early neural programming and brain health in adulthood. A potential treatment mechanism to reverse the effects of ELS on Bdnf expression is aerobic exercise due to its neuroprotective properties and positive impact on Bdnf expression. Aerobic exercise opens the door to exciting and novel potential treatment strategies because it is a behavioral intervention readily and freely available to the public. In this review, we discuss the current literature investigating the use of exercise interventions in animal models of ELS to reverse or mitigate ELS-induced changes in Bdnf expression. We also encourage future studies to investigate sensitive periods of exercise exposure, as well as sufficient duration of exposure, on epigenetic and behavioral outcomes to help lead to standardized practices in the exercise intervention field. MDPI 2022-10-03 /pmc/articles/PMC9569911/ /pubmed/36233029 http://dx.doi.org/10.3390/ijms231911729 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Campbell, Taylor S.
Donoghue, Katelyn M.
Ghosh, Urmi
Nelson, Christina M.
Roth, Tania L.
Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions
title Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions
title_full Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions
title_fullStr Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions
title_full_unstemmed Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions
title_short Early Life Stress Affects Bdnf Regulation: A Role for Exercise Interventions
title_sort early life stress affects bdnf regulation: a role for exercise interventions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569911/
https://www.ncbi.nlm.nih.gov/pubmed/36233029
http://dx.doi.org/10.3390/ijms231911729
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