Discovery and In Vivo Efficacy of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 4-(2-Aminoethyl)-N-(3,5-dimethylphenyl)piperidine-1-carboxamide Hydrochloride (AP163) for the Treatment of Psychotic Disorders

Starting from a screening hit, a set of analogs was synthesized based on a 4-(2-aminoethyl)piperidine core not associated previously with trace amine-associated receptor 1 (TAAR1) modulation in the literature. Several structure–activity relationship generalizations have been drawn from the observed...

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Detalles Bibliográficos
Autores principales: Krasavin, Mikhail, Peshkov, Anatoly A., Lukin, Alexey, Komarova, Kristina, Vinogradova, Lyubov, Smirnova, Daria, Kanov, Evgeny V., Kuvarzin, Savelii R., Murtazina, Ramilya Z., Efimova, Evgeniya V., Gureev, Maxim, Onokhin, Kirill, Zakharov, Konstantin, Gainetdinov, Raul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569940/
https://www.ncbi.nlm.nih.gov/pubmed/36232878
http://dx.doi.org/10.3390/ijms231911579

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