Cargando…

New Oxazolo[5,4-d]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research

Cancer is a large group of diseases in which the rapid proliferation of abnormal cells generally leads to metastasis to surrounding tissues or more distant ones through the lymphatic and blood vessels, making it the second leading cause of death worldwide. The main challenge in designing a modern an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sochacka-Ćwikła, Aleksandra, Mączyński, Marcin, Czyżnikowska, Żaneta, Wiatrak, Benita, Jęśkowiak, Izabela, Czerski, Albert, Regiec, Andrzej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569971/ https://www.ncbi.nlm.nih.gov/pubmed/36232997 http://dx.doi.org/10.3390/ijms231911694

Ejemplares similares

Synthesis and Biological Activity of New 7-Amino-oxazolo[5,4-d]Pyrimidine Derivatives
por: Sochacka-Ćwikła, Aleksandra, et al.
Publicado: (2020)

FDA-Approved Small Molecule Compounds as Drugs for Solid Cancers from Early 2011 to the End of 2021
por: Sochacka-Ćwikła, Aleksandra, et al.
Publicado: (2022)

FDA-Approved Drugs for Hematological Malignancies—The Last Decade Review
por: Sochacka-Ćwikła, Aleksandra, et al.
Publicado: (2021)

Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4,6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl]pyrrolo[3,4-c]pyrrole-1,3(2H,5H)-diones as Anti-Inflammatory Agents with Dual Inhibition of COX and LOX
por: Redzicka, Aleksandra, et al.
Publicado: (2023)

Novel Pyrimidine Derivatives as Potential Anticancer Agents: Synthesis, Biological Evaluation and Molecular Docking Study
por: Tylińska, Beata, et al.
Publicado: (2021)

Synthesis, Physicochemical Characteristics and Plausible Mechanism of Action of an Immunosuppressive Isoxazolo[5,4-e]-1,2,4-Triazepine Derivative (RM33)
por: Mączyński, Marcin, et al.
Publicado: (2021)

Preclinical Study of Immunological Isoxazole Derivatives as a Potential Support for Melanoma Chemotherapy
por: Jęśkowiak, Izabela, et al.
Publicado: (2021)

Design and Synthesis of N-Substituted 3,4-Pyrroledicarboximides as Potential Anti-Inflammatory Agents
por: Redzicka, Aleksandra, et al.
Publicado: (2021)

Investigation of the Properties of Linen Fibers and Dressings
por: Gębarowski, Tomasz, et al.
Publicado: (2022)

Oils from Transgenic Flax Lines as Potential Chemopreventive Agents in Colorectal Cancer
por: Gębarowski, Tomasz, et al.
Publicado: (2023)

Synthesis of New Tricyclic 1,2-Thiazine Derivatives with Anti-Inflammatory Activity
por: Maniewska, Jadwiga, et al.
Publicado: (2021)

Patients’ Habits and the Role of Pharmacists and Telemedicine as Elements of a Modern Health Care System during the COVID-19 Pandemic
por: Grosman-Dziewiszek, Patrycja, et al.
Publicado: (2021)

The Incidence and Severity of Post-Vaccination Reactions after Vaccination against COVID-19
por: Jęśkowiak, Izabela, et al.
Publicado: (2021)

Does Inflammation Play a Major Role in the Pathogenesis of Alzheimer's Disease?
por: Wiatrak, Benita, et al.
Publicado: (2023)

In Vitro and In Silico Evaluation of New 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone as Promising Cyclooxygenase Inhibitors
por: Peregrym, Krzysztof, et al.
Publicado: (2021)

New 1,3,4-Oxadiazole Derivatives of Pyridothiazine-1,1-Dioxide with Anti-Inflammatory Activity
por: Glomb, Teresa, et al.
Publicado: (2020)

The Technological Process of Obtaining New Linen Dressings Did Not Cause the Loss of Their Wound-Healing Properties
por: Gębarowski, Tomasz, et al.
Publicado: (2021)

The Role of the Microbiota-Gut-Brain Axis in the Development of Alzheimer’s Disease
por: Wiatrak, Benita, et al.
Publicado: (2022)

Novel insights on [1,2]oxazolo[5,4‐e]isoindoles on multidrug resistant acute myeloid leukemia cell line
por: Labbozzetta, Manuela, et al.
Publicado: (2022)

The N’-Substituted Derivatives of 5-Chloro-3-Methylisothiazole-4-Carboxylic Acid Hydrazide with Antiproliferative Activity
por: Jęśkowiak, Izabela, et al.
Publicado: (2019)

Simple and Expedient Access to Novel Fluorinated Thiazolo- and Oxazolo[3,2-a]pyrimidin-7-one Derivatives and Their Functionalization via Palladium-Catalyzed Reactions
por: Blancou, Wafa, et al.
Publicado: (2022)

Synthesis of 6-Nitroderivatives of Oxazolo[3,2-a]-pyridines and Their Reactions with Nucleophiles
por: Bush, Alexander A., et al.
Publicado: (2003)

Design, Synthesis and Biological Evaluation of New Pyrimidine Derivatives as Anticancer Agents
por: Madia, Valentina Noemi, et al.
Publicado: (2021)

Sanguinarine-Chelerythrine Fraction of Coptis chinensis Exerts Anti-inflammatory Activity in Carrageenan Paw Oedema Test in Rats and Reveals Reduced Gastrotoxicity
por: Danielewski, Maciej, et al.
Publicado: (2022)

Trehalose Lipid Biosurfactant Reduces Adhesion of Microbial Pathogens to Polystyrene and Silicone Surfaces: An Experimental and Computational Approach
por: Janek, Tomasz, et al.
Publicado: (2018)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

(4S)-3-Methyl-5,6,7,8-tetrahydro-4H-spiro[[1,2]oxazolo[5,4-b]quinoline-4,3′-indole]-2′,5-dione
por: Govindan, E., et al.
Publicado: (2014)

A quantum-chemical study of the binding ability of βXaaHisGlyHis towards copper(II) ion
por: Czyżnikowska, Żaneta, et al.
Publicado: (2011)

Physical nature of intermolecular interactions inside Sir2 homolog active site: molecular dynamics and ab initio study
por: Czeleń, Przemysław, et al.
Publicado: (2016)

Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent
por: El-Kalyoubi, Samar A.
Publicado: (2018)

Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines
por: Monier, M., et al.
Publicado: (2019)

Novel Pyrimidine Derivatives as Antioxidant and Anticancer Agents: Design, Synthesis and Molecular Modeling Studies
por: Myriagkou, Malama, et al.
Publicado: (2023)

New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
por: Al-Tuwaijri, Hanaa M., et al.
Publicado: (2023)

Dakin-West Trick in the Design of Novel 2-Alkyl(aralkyl) Derivatives of Oxazolo[3,2-a]pyridines
por: Kazhkenov, Zeinul-Gabiden M., et al.
Publicado: (2005)

Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity
por: Kciuk, Mateusz, et al.
Publicado: (2023)

Steroidal Pyrimidines and Dihydrotriazines as Novel Classes of Anticancer Agents against Hormone-Dependent Breast Cancer Cells
por: Scherbakov, Alexander M., et al.
Publicado: (2018)

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents
por: Wu, Liqiang, et al.
Publicado: (2018)

(4S)-5′-Chloro-3,7,7-trimethyl-5,6,7,8-tetrahydro-4H-spiro[1,2-oxazolo[5,4-b]quinoline-4,3′-indole]-2′,5-dione
por: Govindan, E., et al.
Publicado: (2014)

The Analysis of Cu(II)/Zn(II) Cyclopeptide System as Potential Cu,ZnSOD Mimic Center
por: Kotynia, Aleksandra, et al.
Publicado: (2017)

Identification of oxazolo[4,5-g]quinazolin-2(1H)-one Derivatives as EGFR Inhibitors for Cancer Prevention
por: Senthil, Renganthan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_djr77ke0oo162ai6dljs99brtl