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Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and vi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569983/ https://www.ncbi.nlm.nih.gov/pubmed/36232800 http://dx.doi.org/10.3390/ijms231911507 |
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author | Dell’Anno, Filippo Vitale, Giovanni Andrea Buonocore, Carmine Vitale, Laura Palma Esposito, Fortunato Coppola, Daniela Della Sala, Gerardo Tedesco, Pietro de Pascale, Donatella |
author_facet | Dell’Anno, Filippo Vitale, Giovanni Andrea Buonocore, Carmine Vitale, Laura Palma Esposito, Fortunato Coppola, Daniela Della Sala, Gerardo Tedesco, Pietro de Pascale, Donatella |
author_sort | Dell’Anno, Filippo |
collection | PubMed |
description | Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and virulence. In this review, we reorganize the information produced in recent years regarding PVDs biosynthesis and pathogenic mechanisms, since PVDs are extremely valuable compounds. Additionally, we summarize the therapeutic applications deriving from the PVDs’ use and focus on their role as therapeutic target themselves. We assess the current biotechnological applications of different sectors and evaluate the state-of-the-art technology relating to the use of synthetic biology tools for pathway engineering. Finally, we review the most recent methods and techniques capable of identifying such molecules in complex matrices for drug-discovery purposes. |
format | Online Article Text |
id | pubmed-9569983 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95699832022-10-17 Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application Dell’Anno, Filippo Vitale, Giovanni Andrea Buonocore, Carmine Vitale, Laura Palma Esposito, Fortunato Coppola, Daniela Della Sala, Gerardo Tedesco, Pietro de Pascale, Donatella Int J Mol Sci Review Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and virulence. In this review, we reorganize the information produced in recent years regarding PVDs biosynthesis and pathogenic mechanisms, since PVDs are extremely valuable compounds. Additionally, we summarize the therapeutic applications deriving from the PVDs’ use and focus on their role as therapeutic target themselves. We assess the current biotechnological applications of different sectors and evaluate the state-of-the-art technology relating to the use of synthetic biology tools for pathway engineering. Finally, we review the most recent methods and techniques capable of identifying such molecules in complex matrices for drug-discovery purposes. MDPI 2022-09-29 /pmc/articles/PMC9569983/ /pubmed/36232800 http://dx.doi.org/10.3390/ijms231911507 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Dell’Anno, Filippo Vitale, Giovanni Andrea Buonocore, Carmine Vitale, Laura Palma Esposito, Fortunato Coppola, Daniela Della Sala, Gerardo Tedesco, Pietro de Pascale, Donatella Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application |
title | Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application |
title_full | Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application |
title_fullStr | Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application |
title_full_unstemmed | Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application |
title_short | Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application |
title_sort | novel insights on pyoverdine: from biosynthesis to biotechnological application |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569983/ https://www.ncbi.nlm.nih.gov/pubmed/36232800 http://dx.doi.org/10.3390/ijms231911507 |
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