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Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application

Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and vi...

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Autores principales: Dell’Anno, Filippo, Vitale, Giovanni Andrea, Buonocore, Carmine, Vitale, Laura, Palma Esposito, Fortunato, Coppola, Daniela, Della Sala, Gerardo, Tedesco, Pietro, de Pascale, Donatella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569983/
https://www.ncbi.nlm.nih.gov/pubmed/36232800
http://dx.doi.org/10.3390/ijms231911507
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author Dell’Anno, Filippo
Vitale, Giovanni Andrea
Buonocore, Carmine
Vitale, Laura
Palma Esposito, Fortunato
Coppola, Daniela
Della Sala, Gerardo
Tedesco, Pietro
de Pascale, Donatella
author_facet Dell’Anno, Filippo
Vitale, Giovanni Andrea
Buonocore, Carmine
Vitale, Laura
Palma Esposito, Fortunato
Coppola, Daniela
Della Sala, Gerardo
Tedesco, Pietro
de Pascale, Donatella
author_sort Dell’Anno, Filippo
collection PubMed
description Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and virulence. In this review, we reorganize the information produced in recent years regarding PVDs biosynthesis and pathogenic mechanisms, since PVDs are extremely valuable compounds. Additionally, we summarize the therapeutic applications deriving from the PVDs’ use and focus on their role as therapeutic target themselves. We assess the current biotechnological applications of different sectors and evaluate the state-of-the-art technology relating to the use of synthetic biology tools for pathway engineering. Finally, we review the most recent methods and techniques capable of identifying such molecules in complex matrices for drug-discovery purposes.
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spelling pubmed-95699832022-10-17 Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application Dell’Anno, Filippo Vitale, Giovanni Andrea Buonocore, Carmine Vitale, Laura Palma Esposito, Fortunato Coppola, Daniela Della Sala, Gerardo Tedesco, Pietro de Pascale, Donatella Int J Mol Sci Review Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron necessary for cell metabolism. Moreover, PVDs also play a crucial role in microbes’ survival by mediating biofilm formation and virulence. In this review, we reorganize the information produced in recent years regarding PVDs biosynthesis and pathogenic mechanisms, since PVDs are extremely valuable compounds. Additionally, we summarize the therapeutic applications deriving from the PVDs’ use and focus on their role as therapeutic target themselves. We assess the current biotechnological applications of different sectors and evaluate the state-of-the-art technology relating to the use of synthetic biology tools for pathway engineering. Finally, we review the most recent methods and techniques capable of identifying such molecules in complex matrices for drug-discovery purposes. MDPI 2022-09-29 /pmc/articles/PMC9569983/ /pubmed/36232800 http://dx.doi.org/10.3390/ijms231911507 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dell’Anno, Filippo
Vitale, Giovanni Andrea
Buonocore, Carmine
Vitale, Laura
Palma Esposito, Fortunato
Coppola, Daniela
Della Sala, Gerardo
Tedesco, Pietro
de Pascale, Donatella
Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
title Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
title_full Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
title_fullStr Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
title_full_unstemmed Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
title_short Novel Insights on Pyoverdine: From Biosynthesis to Biotechnological Application
title_sort novel insights on pyoverdine: from biosynthesis to biotechnological application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9569983/
https://www.ncbi.nlm.nih.gov/pubmed/36232800
http://dx.doi.org/10.3390/ijms231911507
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