Targeting Signaling Pathway Downstream of RIG-I/MAVS in the CNS Stimulates Production of Endogenous Type I IFN and Suppresses EAE

Type I interferons (IFN), including IFNβ, play a protective role in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Type I IFNs are induced by the stimulation of innate signaling, including via cytoplasmic RIG-I-like receptors. In the present study, we...

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Detalles Bibliográficos
Autores principales: Kronborg Hansen, Anne K., Dubik, Magdalena, Marczynska, Joanna, Ojha, Bhavya, Nistal-Villán, Estanislao, González Aseguinolaza, Gloria, Arengoth, Dina S., Owens, Trevor, Khorooshi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570082/
https://www.ncbi.nlm.nih.gov/pubmed/36232593
http://dx.doi.org/10.3390/ijms231911292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570082/
https://www.ncbi.nlm.nih.gov/pubmed/36232593
http://dx.doi.org/10.3390/ijms231911292

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