New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies

Glycoporphyrins are group of compounds of high value for the purpose of photodynamic therapy and other biomedical applications. Despite great progress in the field, new diversity-oriented syntheses of carbohydrate-porphyrin hybrids are increasingly desired. Herein, we present efficient, mild, and me...

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Autores principales: Rosa, Mariusz, Jędryka, Natalia, Skorupska, Sandra, Grabowska-Jadach, Ilona, Malinowski, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570116/
https://www.ncbi.nlm.nih.gov/pubmed/36232622
http://dx.doi.org/10.3390/ijms231911321
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author Rosa, Mariusz
Jędryka, Natalia
Skorupska, Sandra
Grabowska-Jadach, Ilona
Malinowski, Maciej
author_facet Rosa, Mariusz
Jędryka, Natalia
Skorupska, Sandra
Grabowska-Jadach, Ilona
Malinowski, Maciej
author_sort Rosa, Mariusz
collection PubMed
description Glycoporphyrins are group of compounds of high value for the purpose of photodynamic therapy and other biomedical applications. Despite great progress in the field, new diversity-oriented syntheses of carbohydrate-porphyrin hybrids are increasingly desired. Herein, we present efficient, mild, and metal-free conditions for synthesis of glycoporphyrins. The versatile nature of the S(N)Ar procedure is presented in 16 examples. Preliminary biological studies have been conducted on the cytotoxicity and cellular uptake of the final molecules.
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spelling pubmed-95701162022-10-17 New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies Rosa, Mariusz Jędryka, Natalia Skorupska, Sandra Grabowska-Jadach, Ilona Malinowski, Maciej Int J Mol Sci Article Glycoporphyrins are group of compounds of high value for the purpose of photodynamic therapy and other biomedical applications. Despite great progress in the field, new diversity-oriented syntheses of carbohydrate-porphyrin hybrids are increasingly desired. Herein, we present efficient, mild, and metal-free conditions for synthesis of glycoporphyrins. The versatile nature of the S(N)Ar procedure is presented in 16 examples. Preliminary biological studies have been conducted on the cytotoxicity and cellular uptake of the final molecules. MDPI 2022-09-26 /pmc/articles/PMC9570116/ /pubmed/36232622 http://dx.doi.org/10.3390/ijms231911321 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rosa, Mariusz
Jędryka, Natalia
Skorupska, Sandra
Grabowska-Jadach, Ilona
Malinowski, Maciej
New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies
title New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies
title_full New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies
title_fullStr New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies
title_full_unstemmed New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies
title_short New Route to Glycosylated Porphyrins via Aromatic Nucleophilic Substitution (S(N)Ar)—Synthesis and Cellular Uptake Studies
title_sort new route to glycosylated porphyrins via aromatic nucleophilic substitution (s(n)ar)—synthesis and cellular uptake studies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570116/
https://www.ncbi.nlm.nih.gov/pubmed/36232622
http://dx.doi.org/10.3390/ijms231911321
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