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Polyphenols as Potent Epigenetics Agents for Cancer

Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such...

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Autores principales: Rajendran, Peramaiyan, Abdelsalam, Salaheldin Abdelraouf, Renu, Kaviyarasi, Veeraraghavan, Vishnupriya, Ben Ammar, Rebai, Ahmed, Emad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570183/
https://www.ncbi.nlm.nih.gov/pubmed/36233012
http://dx.doi.org/10.3390/ijms231911712
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author Rajendran, Peramaiyan
Abdelsalam, Salaheldin Abdelraouf
Renu, Kaviyarasi
Veeraraghavan, Vishnupriya
Ben Ammar, Rebai
Ahmed, Emad A.
author_facet Rajendran, Peramaiyan
Abdelsalam, Salaheldin Abdelraouf
Renu, Kaviyarasi
Veeraraghavan, Vishnupriya
Ben Ammar, Rebai
Ahmed, Emad A.
author_sort Rajendran, Peramaiyan
collection PubMed
description Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity.
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spelling pubmed-95701832022-10-17 Polyphenols as Potent Epigenetics Agents for Cancer Rajendran, Peramaiyan Abdelsalam, Salaheldin Abdelraouf Renu, Kaviyarasi Veeraraghavan, Vishnupriya Ben Ammar, Rebai Ahmed, Emad A. Int J Mol Sci Review Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity. MDPI 2022-10-03 /pmc/articles/PMC9570183/ /pubmed/36233012 http://dx.doi.org/10.3390/ijms231911712 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rajendran, Peramaiyan
Abdelsalam, Salaheldin Abdelraouf
Renu, Kaviyarasi
Veeraraghavan, Vishnupriya
Ben Ammar, Rebai
Ahmed, Emad A.
Polyphenols as Potent Epigenetics Agents for Cancer
title Polyphenols as Potent Epigenetics Agents for Cancer
title_full Polyphenols as Potent Epigenetics Agents for Cancer
title_fullStr Polyphenols as Potent Epigenetics Agents for Cancer
title_full_unstemmed Polyphenols as Potent Epigenetics Agents for Cancer
title_short Polyphenols as Potent Epigenetics Agents for Cancer
title_sort polyphenols as potent epigenetics agents for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570183/
https://www.ncbi.nlm.nih.gov/pubmed/36233012
http://dx.doi.org/10.3390/ijms231911712
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