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Polyphenols as Potent Epigenetics Agents for Cancer
Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570183/ https://www.ncbi.nlm.nih.gov/pubmed/36233012 http://dx.doi.org/10.3390/ijms231911712 |
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author | Rajendran, Peramaiyan Abdelsalam, Salaheldin Abdelraouf Renu, Kaviyarasi Veeraraghavan, Vishnupriya Ben Ammar, Rebai Ahmed, Emad A. |
author_facet | Rajendran, Peramaiyan Abdelsalam, Salaheldin Abdelraouf Renu, Kaviyarasi Veeraraghavan, Vishnupriya Ben Ammar, Rebai Ahmed, Emad A. |
author_sort | Rajendran, Peramaiyan |
collection | PubMed |
description | Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity. |
format | Online Article Text |
id | pubmed-9570183 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95701832022-10-17 Polyphenols as Potent Epigenetics Agents for Cancer Rajendran, Peramaiyan Abdelsalam, Salaheldin Abdelraouf Renu, Kaviyarasi Veeraraghavan, Vishnupriya Ben Ammar, Rebai Ahmed, Emad A. Int J Mol Sci Review Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity. MDPI 2022-10-03 /pmc/articles/PMC9570183/ /pubmed/36233012 http://dx.doi.org/10.3390/ijms231911712 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rajendran, Peramaiyan Abdelsalam, Salaheldin Abdelraouf Renu, Kaviyarasi Veeraraghavan, Vishnupriya Ben Ammar, Rebai Ahmed, Emad A. Polyphenols as Potent Epigenetics Agents for Cancer |
title | Polyphenols as Potent Epigenetics Agents for Cancer |
title_full | Polyphenols as Potent Epigenetics Agents for Cancer |
title_fullStr | Polyphenols as Potent Epigenetics Agents for Cancer |
title_full_unstemmed | Polyphenols as Potent Epigenetics Agents for Cancer |
title_short | Polyphenols as Potent Epigenetics Agents for Cancer |
title_sort | polyphenols as potent epigenetics agents for cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570183/ https://www.ncbi.nlm.nih.gov/pubmed/36233012 http://dx.doi.org/10.3390/ijms231911712 |
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