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A Computational QSAR, Molecular Docking and In Vitro Cytotoxicity Study of Novel Thiouracil-Based Drugs with Anticancer Activity against Human-DNA Topoisomerase II

Computational chemistry, molecular docking, and drug design approaches, combined with the biochemical evaluation of the antitumor activity of selected derivatives of the thiouracil-based dihydroindeno pyrido pyrimidines against topoisomerase I and II. The IC50 of other cell lines including the norma...

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Detalles Bibliográficos
Autores principales: Khaled, Doaa M., Elshakre, Mohamed E., Noamaan, Mahmoud A., Butt, Haider, Abdel Fattah, Marwa M., Gaber, Dalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570267/
https://www.ncbi.nlm.nih.gov/pubmed/36233102
http://dx.doi.org/10.3390/ijms231911799

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