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Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovasc...

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Autores principales: Diaconu, Alexandra-Diana, Ceasovschih, Alexandr, Șorodoc, Victorița, Pomîrleanu, Cristina, Lionte, Cătălina, Șorodoc, Laurențiu, Ancuța, Codrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570274/
https://www.ncbi.nlm.nih.gov/pubmed/36232862
http://dx.doi.org/10.3390/ijms231911561
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author Diaconu, Alexandra-Diana
Ceasovschih, Alexandr
Șorodoc, Victorița
Pomîrleanu, Cristina
Lionte, Cătălina
Șorodoc, Laurențiu
Ancuța, Codrina
author_facet Diaconu, Alexandra-Diana
Ceasovschih, Alexandr
Șorodoc, Victorița
Pomîrleanu, Cristina
Lionte, Cătălina
Șorodoc, Laurențiu
Ancuța, Codrina
author_sort Diaconu, Alexandra-Diana
collection PubMed
description Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovascular diseases (CVDs), mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are needed to prevent or decrease functional decline and to improve the patient’s prognosis. In respect of axSpA, there is an unmet need for biomarkers that can help to diagnose the disease, define disease activity and prognosis, and establish personalized treatment approaches. The aim of this review was to summarize the available information regarding the most promising biomarkers for axSpA. We classified and identified six core categories of biomarkers: (i) systemic markers of inflammation; (ii) molecules involved in bone homeostasis; (iii) HLA-B27 and newer genetic biomarkers; (iv) antibody-based biomarkers; (v) microbiome biomarkers; and (vi) miscellaneous biomarkers. Unfortunately, despite efforts to validate new biomarkers, few of them are used in clinical practice; however, we believe that these studies provide useful data that could aid in better disease management.
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spelling pubmed-95702742022-10-17 Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis Diaconu, Alexandra-Diana Ceasovschih, Alexandr Șorodoc, Victorița Pomîrleanu, Cristina Lionte, Cătălina Șorodoc, Laurențiu Ancuța, Codrina Int J Mol Sci Review Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovascular diseases (CVDs), mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are needed to prevent or decrease functional decline and to improve the patient’s prognosis. In respect of axSpA, there is an unmet need for biomarkers that can help to diagnose the disease, define disease activity and prognosis, and establish personalized treatment approaches. The aim of this review was to summarize the available information regarding the most promising biomarkers for axSpA. We classified and identified six core categories of biomarkers: (i) systemic markers of inflammation; (ii) molecules involved in bone homeostasis; (iii) HLA-B27 and newer genetic biomarkers; (iv) antibody-based biomarkers; (v) microbiome biomarkers; and (vi) miscellaneous biomarkers. Unfortunately, despite efforts to validate new biomarkers, few of them are used in clinical practice; however, we believe that these studies provide useful data that could aid in better disease management. MDPI 2022-09-30 /pmc/articles/PMC9570274/ /pubmed/36232862 http://dx.doi.org/10.3390/ijms231911561 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Diaconu, Alexandra-Diana
Ceasovschih, Alexandr
Șorodoc, Victorița
Pomîrleanu, Cristina
Lionte, Cătălina
Șorodoc, Laurențiu
Ancuța, Codrina
Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
title Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
title_full Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
title_fullStr Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
title_full_unstemmed Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
title_short Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
title_sort practical significance of biomarkers in axial spondyloarthritis: updates on diagnosis, disease activity, and prognosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570274/
https://www.ncbi.nlm.nih.gov/pubmed/36232862
http://dx.doi.org/10.3390/ijms231911561
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