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Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovasc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570274/ https://www.ncbi.nlm.nih.gov/pubmed/36232862 http://dx.doi.org/10.3390/ijms231911561 |
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author | Diaconu, Alexandra-Diana Ceasovschih, Alexandr Șorodoc, Victorița Pomîrleanu, Cristina Lionte, Cătălina Șorodoc, Laurențiu Ancuța, Codrina |
author_facet | Diaconu, Alexandra-Diana Ceasovschih, Alexandr Șorodoc, Victorița Pomîrleanu, Cristina Lionte, Cătălina Șorodoc, Laurențiu Ancuța, Codrina |
author_sort | Diaconu, Alexandra-Diana |
collection | PubMed |
description | Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovascular diseases (CVDs), mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are needed to prevent or decrease functional decline and to improve the patient’s prognosis. In respect of axSpA, there is an unmet need for biomarkers that can help to diagnose the disease, define disease activity and prognosis, and establish personalized treatment approaches. The aim of this review was to summarize the available information regarding the most promising biomarkers for axSpA. We classified and identified six core categories of biomarkers: (i) systemic markers of inflammation; (ii) molecules involved in bone homeostasis; (iii) HLA-B27 and newer genetic biomarkers; (iv) antibody-based biomarkers; (v) microbiome biomarkers; and (vi) miscellaneous biomarkers. Unfortunately, despite efforts to validate new biomarkers, few of them are used in clinical practice; however, we believe that these studies provide useful data that could aid in better disease management. |
format | Online Article Text |
id | pubmed-9570274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95702742022-10-17 Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis Diaconu, Alexandra-Diana Ceasovschih, Alexandr Șorodoc, Victorița Pomîrleanu, Cristina Lionte, Cătălina Șorodoc, Laurențiu Ancuța, Codrina Int J Mol Sci Review Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that can lead to ankylosis by secondary ossification of inflammatory lesions, with progressive disability and a significant impact on quality of life. It is also a risk factor for the occurrence of comorbidities, especially cardiovascular diseases (CVDs), mood disorders, osteoporosis, and malignancies. Early diagnosis and treatment are needed to prevent or decrease functional decline and to improve the patient’s prognosis. In respect of axSpA, there is an unmet need for biomarkers that can help to diagnose the disease, define disease activity and prognosis, and establish personalized treatment approaches. The aim of this review was to summarize the available information regarding the most promising biomarkers for axSpA. We classified and identified six core categories of biomarkers: (i) systemic markers of inflammation; (ii) molecules involved in bone homeostasis; (iii) HLA-B27 and newer genetic biomarkers; (iv) antibody-based biomarkers; (v) microbiome biomarkers; and (vi) miscellaneous biomarkers. Unfortunately, despite efforts to validate new biomarkers, few of them are used in clinical practice; however, we believe that these studies provide useful data that could aid in better disease management. MDPI 2022-09-30 /pmc/articles/PMC9570274/ /pubmed/36232862 http://dx.doi.org/10.3390/ijms231911561 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Diaconu, Alexandra-Diana Ceasovschih, Alexandr Șorodoc, Victorița Pomîrleanu, Cristina Lionte, Cătălina Șorodoc, Laurențiu Ancuța, Codrina Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis |
title | Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis |
title_full | Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis |
title_fullStr | Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis |
title_full_unstemmed | Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis |
title_short | Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis |
title_sort | practical significance of biomarkers in axial spondyloarthritis: updates on diagnosis, disease activity, and prognosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570274/ https://www.ncbi.nlm.nih.gov/pubmed/36232862 http://dx.doi.org/10.3390/ijms231911561 |
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