Age-Related Low Bone Mineral Density in C57BL/6 Mice Is Reflective of Aberrant Bone Morphogenetic Protein-2 Signaling Observed in Human Patients Diagnosed with Osteoporosis

Osteoporosis (OP) is a bone disorder characterized by decreased bone mineral density (BMD). Bone Morphogenetic Protein-2 (BMP-2) injections are used to promote bone formation in OP patients. However, patients are unresponsive to BMP-2 while displaying an upregulation of BMP Receptor Type 1a (BMPRIa)...

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Detalles Bibliográficos
Autores principales: Halloran, Daniel, Pandit, Venu, MacMurray, Connor, Stone, Victoria, DeGeorge, Kailey, Eskander, Mark, Root, Denise, McTague, Sean, Pelkey, Heather, Nohe, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570292/
https://www.ncbi.nlm.nih.gov/pubmed/36232525
http://dx.doi.org/10.3390/ijms231911205

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