Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine

In addition to the fundamental role of insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling dysregulation in cancer initiation and proliferation, the IGF/IGF-1R signaling also plays an important role in the maintenance of stem cell characteristics and enhancement of stem cell-based the...

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Autores principales: Lin, Syuan-Ling, Lin, Chih-Yang, Lee, Wei, Teng, Chiao-Fang, Shyu, Woei-Cherng, Jeng, Long-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570316/
https://www.ncbi.nlm.nih.gov/pubmed/36233084
http://dx.doi.org/10.3390/ijms231911781
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author Lin, Syuan-Ling
Lin, Chih-Yang
Lee, Wei
Teng, Chiao-Fang
Shyu, Woei-Cherng
Jeng, Long-Bin
author_facet Lin, Syuan-Ling
Lin, Chih-Yang
Lee, Wei
Teng, Chiao-Fang
Shyu, Woei-Cherng
Jeng, Long-Bin
author_sort Lin, Syuan-Ling
collection PubMed
description In addition to the fundamental role of insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling dysregulation in cancer initiation and proliferation, the IGF/IGF-1R signaling also plays an important role in the maintenance of stem cell characteristics and enhancement of stem cell-based therapeutic efficacy. This review focused on the role of IGF/IGF-1R signaling in preclinical IGF-targeted therapies, including IGF-1R monoclonal antibodies, IGF-1R tyrosine kinase inhibitors, and neutralizing antibodies of IGFs in multiple tumors and endocrine disorders. On the other hand, the function of IGF/IGF-1R signaling in stem cell self-renewal, pluripotency and therapeutic efficacy in regenerative medicine was outlined. Finally, the review summarized ongoing studies on IGF/IGF-1R signaling blockade in multiple cancers and highlighted the IGF-1R signaling modifications in stem cells as a potential strategy to improve stem cell-based therapeutics in regenerative medicine.
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spelling pubmed-95703162022-10-17 Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine Lin, Syuan-Ling Lin, Chih-Yang Lee, Wei Teng, Chiao-Fang Shyu, Woei-Cherng Jeng, Long-Bin Int J Mol Sci Review In addition to the fundamental role of insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling dysregulation in cancer initiation and proliferation, the IGF/IGF-1R signaling also plays an important role in the maintenance of stem cell characteristics and enhancement of stem cell-based therapeutic efficacy. This review focused on the role of IGF/IGF-1R signaling in preclinical IGF-targeted therapies, including IGF-1R monoclonal antibodies, IGF-1R tyrosine kinase inhibitors, and neutralizing antibodies of IGFs in multiple tumors and endocrine disorders. On the other hand, the function of IGF/IGF-1R signaling in stem cell self-renewal, pluripotency and therapeutic efficacy in regenerative medicine was outlined. Finally, the review summarized ongoing studies on IGF/IGF-1R signaling blockade in multiple cancers and highlighted the IGF-1R signaling modifications in stem cells as a potential strategy to improve stem cell-based therapeutics in regenerative medicine. MDPI 2022-10-04 /pmc/articles/PMC9570316/ /pubmed/36233084 http://dx.doi.org/10.3390/ijms231911781 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Syuan-Ling
Lin, Chih-Yang
Lee, Wei
Teng, Chiao-Fang
Shyu, Woei-Cherng
Jeng, Long-Bin
Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine
title Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine
title_full Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine
title_fullStr Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine
title_full_unstemmed Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine
title_short Mini Review: Molecular Interpretation of the IGF/IGF-1R Axis in Cancer Treatment and Stem Cells-Based Therapy in Regenerative Medicine
title_sort mini review: molecular interpretation of the igf/igf-1r axis in cancer treatment and stem cells-based therapy in regenerative medicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570316/
https://www.ncbi.nlm.nih.gov/pubmed/36233084
http://dx.doi.org/10.3390/ijms231911781
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