A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines

Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the corresponding quinoxalines as sole, easily isolaable products. The featured transformation involves unusual extrusion of phenylacetonitrile molecule and...

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Detalles Bibliográficos
Autores principales: Aksenov, Alexander V., Arutiunov, Nikolai A., Aksenov, Dmitrii A., Samovolov, Artem V., Kurenkov, Igor A., Aksenov, Nicolai A., Aleksandrova, Elena A., Momotova, Daria S., Rubin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570350/
https://www.ncbi.nlm.nih.gov/pubmed/36232422
http://dx.doi.org/10.3390/ijms231911120
Descripción
Sumario:Microwave-assisted reaction between 2-(3-oxoindolin-2-yl)-2-phenylacetonitriles andbenzene-1,2-diamines leads to the high-yielding formation of the corresponding quinoxalines as sole, easily isolaable products. The featured transformation involves unusual extrusion of phenylacetonitrile molecule and could be performed in a short sequence starting from commonly available indoles and nitroolefins.

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