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Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response

The yeast Saccharomyces cerevisiae has been used for bread making and beer brewing for thousands of years. In addition, its ease of manipulation, well-annotated genome, expansive molecular toolbox, and its strong conservation of basic eukaryotic biology also make it a prime model for eukaryotic cell...

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Autores principales: Vanderwaeren, Laura, Dok, Rüveyda, Voordeckers, Karin, Nuyts, Sandra, Verstrepen, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570374/
https://www.ncbi.nlm.nih.gov/pubmed/36232965
http://dx.doi.org/10.3390/ijms231911665
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author Vanderwaeren, Laura
Dok, Rüveyda
Voordeckers, Karin
Nuyts, Sandra
Verstrepen, Kevin J.
author_facet Vanderwaeren, Laura
Dok, Rüveyda
Voordeckers, Karin
Nuyts, Sandra
Verstrepen, Kevin J.
author_sort Vanderwaeren, Laura
collection PubMed
description The yeast Saccharomyces cerevisiae has been used for bread making and beer brewing for thousands of years. In addition, its ease of manipulation, well-annotated genome, expansive molecular toolbox, and its strong conservation of basic eukaryotic biology also make it a prime model for eukaryotic cell biology and genetics. In this review, we discuss the characteristics that made yeast such an extensively used model organism and specifically focus on the DNA damage response pathway as a prime example of how research in S. cerevisiae helped elucidate a highly conserved biological process. In addition, we also highlight differences in the DNA damage response of S. cerevisiae and humans and discuss the challenges of using S. cerevisiae as a model system.
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spelling pubmed-95703742022-10-17 Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response Vanderwaeren, Laura Dok, Rüveyda Voordeckers, Karin Nuyts, Sandra Verstrepen, Kevin J. Int J Mol Sci Review The yeast Saccharomyces cerevisiae has been used for bread making and beer brewing for thousands of years. In addition, its ease of manipulation, well-annotated genome, expansive molecular toolbox, and its strong conservation of basic eukaryotic biology also make it a prime model for eukaryotic cell biology and genetics. In this review, we discuss the characteristics that made yeast such an extensively used model organism and specifically focus on the DNA damage response pathway as a prime example of how research in S. cerevisiae helped elucidate a highly conserved biological process. In addition, we also highlight differences in the DNA damage response of S. cerevisiae and humans and discuss the challenges of using S. cerevisiae as a model system. MDPI 2022-10-01 /pmc/articles/PMC9570374/ /pubmed/36232965 http://dx.doi.org/10.3390/ijms231911665 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vanderwaeren, Laura
Dok, Rüveyda
Voordeckers, Karin
Nuyts, Sandra
Verstrepen, Kevin J.
Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
title Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
title_full Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
title_fullStr Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
title_full_unstemmed Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
title_short Saccharomyces cerevisiae as a Model System for Eukaryotic Cell Biology, from Cell Cycle Control to DNA Damage Response
title_sort saccharomyces cerevisiae as a model system for eukaryotic cell biology, from cell cycle control to dna damage response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570374/
https://www.ncbi.nlm.nih.gov/pubmed/36232965
http://dx.doi.org/10.3390/ijms231911665
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