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Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel

Vascular replacement is one of the most effective tools to solve cardiovascular diseases, but due to the limitations of autologous transplantation, size mismatch, etc., the blood vessels for replacement are often in short supply. The emergence of artificial blood vessels with 3D bioprinting has been...

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Detalles Bibliográficos
Autores principales: Jin, Wenyu, Liu, Huanbao, Li, Zihan, Nie, Ping, Zhao, Guangxi, Cheng, Xiang, Zheng, Guangming, Yang, Xianhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570380/
https://www.ncbi.nlm.nih.gov/pubmed/36232417
http://dx.doi.org/10.3390/ijms231911114
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author Jin, Wenyu
Liu, Huanbao
Li, Zihan
Nie, Ping
Zhao, Guangxi
Cheng, Xiang
Zheng, Guangming
Yang, Xianhai
author_facet Jin, Wenyu
Liu, Huanbao
Li, Zihan
Nie, Ping
Zhao, Guangxi
Cheng, Xiang
Zheng, Guangming
Yang, Xianhai
author_sort Jin, Wenyu
collection PubMed
description Vascular replacement is one of the most effective tools to solve cardiovascular diseases, but due to the limitations of autologous transplantation, size mismatch, etc., the blood vessels for replacement are often in short supply. The emergence of artificial blood vessels with 3D bioprinting has been expected to solve this problem. Blood vessel prosthesis plays an important role in the field of cardiovascular medical materials. However, a small-diameter blood vessel prosthesis (diameter < 6 mm) is still unable to achieve wide clinical application. In this paper, a response surface analysis was firstly utilized to obtain the relationship between the contact angle and the gelatin/sodium alginate mixed hydrogel solution at different temperatures and mass percentages. Then, the self-developed 3D bioprinter was used to obtain the optimal printing spacing under different conditions through row spacing, printing, and verifying the relationship between the contact angle and the printing thickness. Finally, the relationship between the blood vessel wall thickness and the contact angle was obtained by biofabrication with 3D bioprinting, which can also confirm the controllability of the vascular membrane thickness molding. It lays a foundation for the following study of the small caliber blood vessel printing molding experiment.
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spelling pubmed-95703802022-10-17 Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel Jin, Wenyu Liu, Huanbao Li, Zihan Nie, Ping Zhao, Guangxi Cheng, Xiang Zheng, Guangming Yang, Xianhai Int J Mol Sci Article Vascular replacement is one of the most effective tools to solve cardiovascular diseases, but due to the limitations of autologous transplantation, size mismatch, etc., the blood vessels for replacement are often in short supply. The emergence of artificial blood vessels with 3D bioprinting has been expected to solve this problem. Blood vessel prosthesis plays an important role in the field of cardiovascular medical materials. However, a small-diameter blood vessel prosthesis (diameter < 6 mm) is still unable to achieve wide clinical application. In this paper, a response surface analysis was firstly utilized to obtain the relationship between the contact angle and the gelatin/sodium alginate mixed hydrogel solution at different temperatures and mass percentages. Then, the self-developed 3D bioprinter was used to obtain the optimal printing spacing under different conditions through row spacing, printing, and verifying the relationship between the contact angle and the printing thickness. Finally, the relationship between the blood vessel wall thickness and the contact angle was obtained by biofabrication with 3D bioprinting, which can also confirm the controllability of the vascular membrane thickness molding. It lays a foundation for the following study of the small caliber blood vessel printing molding experiment. MDPI 2022-09-21 /pmc/articles/PMC9570380/ /pubmed/36232417 http://dx.doi.org/10.3390/ijms231911114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jin, Wenyu
Liu, Huanbao
Li, Zihan
Nie, Ping
Zhao, Guangxi
Cheng, Xiang
Zheng, Guangming
Yang, Xianhai
Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel
title Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel
title_full Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel
title_fullStr Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel
title_full_unstemmed Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel
title_short Effect of Hydrogel Contact Angle on Wall Thickness of Artificial Blood Vessel
title_sort effect of hydrogel contact angle on wall thickness of artificial blood vessel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570380/
https://www.ncbi.nlm.nih.gov/pubmed/36232417
http://dx.doi.org/10.3390/ijms231911114
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