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Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective
The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570412/ https://www.ncbi.nlm.nih.gov/pubmed/36233311 http://dx.doi.org/10.3390/ijms231912010 |
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author | Fragiotta, Serena Scuderi, Luca Iodice, Clemente Maria Rullo, Daria Di Pippo, Mariachiara Maugliani, Elisa Abdolrahimzadeh, Solmaz |
author_facet | Fragiotta, Serena Scuderi, Luca Iodice, Clemente Maria Rullo, Daria Di Pippo, Mariachiara Maugliani, Elisa Abdolrahimzadeh, Solmaz |
author_sort | Fragiotta, Serena |
collection | PubMed |
description | The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) expression, complement dysregulation, leukocyte interaction at Bruch’s membrane, and mast cell infiltration of the choroid. A mechanistic link between high-risk genetic loci for AMD and mast cell recruitment has also been recently demonstrated. Recent advances in multimodal imaging allow more detailed visualization of choroidal structure, identifying alterations that may expand our comprehension of aging and AMD development. |
format | Online Article Text |
id | pubmed-9570412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95704122022-10-17 Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective Fragiotta, Serena Scuderi, Luca Iodice, Clemente Maria Rullo, Daria Di Pippo, Mariachiara Maugliani, Elisa Abdolrahimzadeh, Solmaz Int J Mol Sci Review The contribution of choroidal vasculature to the pathogenesis of age-related macular degeneration (AMD) has been long debated. The present narrative review aims to discuss the primary molecular and choroidal structural changes occurring with aging and AMD with a brief overview of the principal multimodal imaging modalities and techniques that enable the optimal in vivo visualization of choroidal modifications. The molecular aspects that target the choroid in AMD mainly involve human leukocyte antigen (HLA) expression, complement dysregulation, leukocyte interaction at Bruch’s membrane, and mast cell infiltration of the choroid. A mechanistic link between high-risk genetic loci for AMD and mast cell recruitment has also been recently demonstrated. Recent advances in multimodal imaging allow more detailed visualization of choroidal structure, identifying alterations that may expand our comprehension of aging and AMD development. MDPI 2022-10-09 /pmc/articles/PMC9570412/ /pubmed/36233311 http://dx.doi.org/10.3390/ijms231912010 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fragiotta, Serena Scuderi, Luca Iodice, Clemente Maria Rullo, Daria Di Pippo, Mariachiara Maugliani, Elisa Abdolrahimzadeh, Solmaz Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective |
title | Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective |
title_full | Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective |
title_fullStr | Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective |
title_full_unstemmed | Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective |
title_short | Choroidal Vasculature Changes in Age-Related Macular Degeneration: From a Molecular to a Clinical Perspective |
title_sort | choroidal vasculature changes in age-related macular degeneration: from a molecular to a clinical perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570412/ https://www.ncbi.nlm.nih.gov/pubmed/36233311 http://dx.doi.org/10.3390/ijms231912010 |
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