Cargando…

Deep-Learning to Predict BRCA Mutation and Survival from Digital H&E Slides of Epithelial Ovarian Cancer

BRCA 1/2 genes mutation status can already determine the therapeutic algorithm of high grade serous ovarian cancer patients. Nevertheless, its assessment is not sufficient to identify all patients with genomic instability, since BRCA 1/2 mutations are only the most well-known mechanisms of homologou...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nero, Camilla, Boldrini, Luca, Lenkowicz, Jacopo, Giudice, Maria Teresa, Piermattei, Alessia, Inzani, Frediano, Pasciuto, Tina, Minucci, Angelo, Fagotti, Anna, Zannoni, Gianfranco, Valentini, Vincenzo, Scambia, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570450/ https://www.ncbi.nlm.nih.gov/pubmed/36232628 http://dx.doi.org/10.3390/ijms231911326

Ejemplares similares

Germline BRCA 1-2 status prediction through ovarian ultrasound images radiogenomics: a hypothesis generating study (PROBE study)
por: Nero, Camilla, et al.
Publicado: (2020)

Further refining 2020 ESGO/ESTRO/ESP molecular risk classes in patients with early‐stage endometrial cancer: A propensity score–matched analysis
por: Nero, Camilla, et al.
Publicado: (2022)

Pathological Chemotherapy Response Score in Patients Affected by High Grade Serous Ovarian Carcinoma: The Prognostic Role of Omental and Ovarian Residual Disease
por: Santoro, Angela, et al.
Publicado: (2019)

PD-L1 Expression on Circulating Tumour-Derived Microvesicles as a Complementary Tool for Stratification of High-Grade Serous Ovarian Cancer Patients
por: Battaglia, Alessandra, et al.
Publicado: (2021)

The Vulvar Immunohistochemical Panel (VIP) Project: Molecular Profiles of Vulvar Squamous Cell Carcinoma
por: Garganese, Giorgia, et al.
Publicado: (2021)

Integrating a Comprehensive Cancer Genome Profiling into Clinical Practice: A Blueprint in an Italian Referral Center
por: Nero, Camilla, et al.
Publicado: (2022)

One-Step Nucleic Acid Amplification (OSNA): A fast molecular test based on CK19 mRNA concentration for assessment of lymph-nodes metastases in early stage endometrial cancer
por: Fanfani, Francesco, et al.
Publicado: (2018)

Diagnostic performance of preoperative [(18)F]FDG-PET/CT for lymph node staging in vulvar cancer: a large single-centre study
por: Rufini, Vittoria, et al.
Publicado: (2021)

A commentary on the discrepancy between blood and tumour BRCA testing: An open question
por: De Paolis, Elisa, et al.
Publicado: (2022)

Neuroendocrine Carcinoma of the Uterine Cervix: A Clinicopathologic and Immunohistochemical Study with Focus on Novel Markers (Sst2–Sst5)
por: Inzani, Frediano, et al.
Publicado: (2020)

What’s beyond BRCA Mutational Status in High Grade Serous Ovarian Cancer? The Impact of Hormone Receptor Expression in a Large BRCA-Profiled Ovarian Cancer Patient Series: A Retrospective Cohort Study
por: Perrone, Emanuele, et al.
Publicado: (2022)

L1CAM Expression in Microcystic, Elongated, and Fragmented (MELF) Glands Predicts Lymph Node Involvement in Endometrial Carcinoma
por: Arciuolo, Damiano, et al.
Publicado: (2022)

Adult Granulosa Cell Tumor in Pregnancy: A New Case and a Review of the Literature
por: Guidi, Sofia, et al.
Publicado: (2021)

Hormonal Environment and HER2 Status in Extra-Mammary Paget’s Disease (eMPD): A Systematic Literature Review and Meta-Analysis with Clinical Considerations
por: Angelico, Giuseppe, et al.
Publicado: (2020)

BRCA testing delay during the COVID-19 pandemic: How to act?
por: Minucci, Angelo, et al.
Publicado: (2020)

Frozen section accurately allows pathological characterization of endometrial cancer in patients with a preoperative ambiguous or inconclusive diagnoses: our experience
por: Santoro, A., et al.
Publicado: (2019)

Biomarker characterization in endometrial cancer in Italy: first survey data analysis
por: Zannoni, Gian Franco, et al.
Publicado: (2022)

Tumor BRCA testing in ovarian cancer and EQA scheme: our experience of a critical evaluation
por: De Paolis, Elisa, et al.
Publicado: (2021)

Failure of ulipristal acetate treatment as an indication for uterine malignancy: Two case reports
por: Santoro, Angela, et al.
Publicado: (2018)

NLR and BRCA mutational status in patients with high grade serous advanced ovarian cancer
por: Marchetti, Claudia, et al.
Publicado: (2021)

Endometrial Metaplastic/Reactive Changes Coexistent with Endometrial Hyperplasia and Carcinoma: A Morphological and Immunohistochemical Study
por: Travaglino, Antonio, et al.
Publicado: (2021)

Role of Homologous Recombination Repair (HRR) Genes in Uterine Leiomyosarcomas: A Retrospective Analysis
por: Ciccarone, Francesca, et al.
Publicado: (2022)

Prognostic Value of Chemotherapy Response Score (CRS) Assessed on the Adnexa in Ovarian High-Grade Serous Carcinoma: A Systematic Review and Meta-Analysis
por: Santoro, Angela, et al.
Publicado: (2022)

Identification of a novel gene signature predicting response to first-line chemotherapy in BRCA wild-type high-grade serous ovarian cancer patients
por: Buttarelli, Marianna, et al.
Publicado: (2022)

BRCA testing in a genomic diagnostics referral center during the COVID-19 pandemic
por: Minucci, Angelo, et al.
Publicado: (2020)

Recent Advances in Cervical Cancer Management: A Review on Novel Prognostic Factors in Primary and Recurrent Tumors
por: Santoro, Angela, et al.
Publicado: (2023)

Pilomatrix-like High-Grade Endometrioid Carcinoma of the Ovary: Case Report, Literature Review, and Differential Diagnosis
por: Santoro, Angela, et al.
Publicado: (2022)

Editorial: Future Perspectives of Sentinel Node Mapping in Gynecological Oncology
por: Santoro, Angela, et al.
Publicado: (2022)

CT-Based Radiomics and Deep Learning for BRCA Mutation and Progression-Free Survival Prediction in Ovarian Cancer Using a Multicentric Dataset
por: Avesani, Giacomo, et al.
Publicado: (2022)

High-resolution melting analysis coupled with next-generation sequencing as a simple tool for the identification of a novel somatic BRCA2 variant: a case report
por: Costella, Alessandra, et al.
Publicado: (2018)

Ultrastaging of the Parametrium in Cervical Cancer: A Clinicopathological Study
por: Bizzarri, Nicolò, et al.
Publicado: (2023)

Artificial Intelligence and OCT Angiography in Full Thickness Macular Hole. New Developments for Personalized Medicine
por: Rizzo, Stanislao, et al.
Publicado: (2021)

Correction: Rizzo et al. Artificial Intelligence and OCT Angiography in Full Thickness Macular Hole. New Developments for Personalized Medicine. Diagnostics 2021, 11, 2319
por: Rizzo, Stanislao, et al.
Publicado: (2022)

Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study
por: Rufini, Vittoria, et al.
Publicado: (2022)

Correction to: Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study
por: Rufini, Vittoria, et al.
Publicado: (2022)

Introduction to neuroendocrine neoplasms of the digestive system: definition and classification
por: Inzani, Frediano, et al.
Publicado: (2021)

Preoperative Tumor Texture Analysis on MRI for High-Risk Disease Prediction in Endometrial Cancer: A Hypothesis-Generating Study
por: Miccò, Maura, et al.
Publicado: (2022)

Prognostic Value of Mandard’s Tumor Regression Grade (TRG) in Post Chemo-Radiotherapy Cervical Cancer
por: Scaglione, Giulia, et al.
Publicado: (2023)

Dual inhibition of CDK12 and CDK13 uncovers actionable vulnerabilities in patient-derived ovarian cancer organoids
por: Cesari, Eleonora, et al.
Publicado: (2023)

Preliminary molecular evidence associating a novel BRCA1 synonymous variant with hereditary ovarian cancer syndrome
por: Minucci, Angelo, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_6bthqnvi2fkcd6deentecs4fr9