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Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease

Backgrounds: We aimed to understand the association between initial vestibular function examination and postural instability (PI) development in Parkinson’s disease (PD). Methods: After screening 51 PD patients, we divided 31 patients into 2 groups based on the presence of PI at the follow-up visit...

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Autores principales: Park, Jeong Ho, Kim, Min Seung, Kang, Suk Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570519/
https://www.ncbi.nlm.nih.gov/pubmed/36233475
http://dx.doi.org/10.3390/jcm11195608
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author Park, Jeong Ho
Kim, Min Seung
Kang, Suk Yun
author_facet Park, Jeong Ho
Kim, Min Seung
Kang, Suk Yun
author_sort Park, Jeong Ho
collection PubMed
description Backgrounds: We aimed to understand the association between initial vestibular function examination and postural instability (PI) development in Parkinson’s disease (PD). Methods: After screening 51 PD patients, we divided 31 patients into 2 groups based on the presence of PI at the follow-up visit and compared the clinical features and vestibular-evoked myogenic potential (VEMP) variables. Results: The mean values of Hoehn and Yahr stage, Unified Parkinson’s Disease Rating Scale (UPDRS) part III, and item 30 (postural stability) of UPDRS were larger in patients with PI at a follow-up visit (p = 0.000, 0.006, 0.048, respectively). In VEMP analyses, the onset latencies of left and right cervical VEMPs were significantly reduced in patients with PI (p = 0.013, 0.040, respectively). Conclusion: We found that the initial VEMP test may be associated with later postural imbalance in PD, suggesting the baseline evaluation may help predict future PI occurrence. A more significant number of patients and more long-term follow-ups are likely to be required for confirmation.
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spelling pubmed-95705192022-10-17 Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease Park, Jeong Ho Kim, Min Seung Kang, Suk Yun J Clin Med Article Backgrounds: We aimed to understand the association between initial vestibular function examination and postural instability (PI) development in Parkinson’s disease (PD). Methods: After screening 51 PD patients, we divided 31 patients into 2 groups based on the presence of PI at the follow-up visit and compared the clinical features and vestibular-evoked myogenic potential (VEMP) variables. Results: The mean values of Hoehn and Yahr stage, Unified Parkinson’s Disease Rating Scale (UPDRS) part III, and item 30 (postural stability) of UPDRS were larger in patients with PI at a follow-up visit (p = 0.000, 0.006, 0.048, respectively). In VEMP analyses, the onset latencies of left and right cervical VEMPs were significantly reduced in patients with PI (p = 0.013, 0.040, respectively). Conclusion: We found that the initial VEMP test may be associated with later postural imbalance in PD, suggesting the baseline evaluation may help predict future PI occurrence. A more significant number of patients and more long-term follow-ups are likely to be required for confirmation. MDPI 2022-09-23 /pmc/articles/PMC9570519/ /pubmed/36233475 http://dx.doi.org/10.3390/jcm11195608 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Jeong Ho
Kim, Min Seung
Kang, Suk Yun
Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
title Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
title_full Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
title_fullStr Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
title_full_unstemmed Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
title_short Initial Vestibular Function May Be Associated with Future Postural Instability in Parkinson’s Disease
title_sort initial vestibular function may be associated with future postural instability in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570519/
https://www.ncbi.nlm.nih.gov/pubmed/36233475
http://dx.doi.org/10.3390/jcm11195608
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