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Allergic Inflammation: Effect of Propolis and Its Flavonoids

The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention...

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Detalles Bibliográficos
Autor principal: Oršolić, Nada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570745/
https://www.ncbi.nlm.nih.gov/pubmed/36235230
http://dx.doi.org/10.3390/molecules27196694
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author Oršolić, Nada
author_facet Oršolić, Nada
author_sort Oršolić, Nada
collection PubMed
description The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.
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spelling pubmed-95707452022-10-17 Allergic Inflammation: Effect of Propolis and Its Flavonoids Oršolić, Nada Molecules Review The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported. MDPI 2022-10-08 /pmc/articles/PMC9570745/ /pubmed/36235230 http://dx.doi.org/10.3390/molecules27196694 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oršolić, Nada
Allergic Inflammation: Effect of Propolis and Its Flavonoids
title Allergic Inflammation: Effect of Propolis and Its Flavonoids
title_full Allergic Inflammation: Effect of Propolis and Its Flavonoids
title_fullStr Allergic Inflammation: Effect of Propolis and Its Flavonoids
title_full_unstemmed Allergic Inflammation: Effect of Propolis and Its Flavonoids
title_short Allergic Inflammation: Effect of Propolis and Its Flavonoids
title_sort allergic inflammation: effect of propolis and its flavonoids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570745/
https://www.ncbi.nlm.nih.gov/pubmed/36235230
http://dx.doi.org/10.3390/molecules27196694
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