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Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts

Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification...

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Autores principales: Muzammil, Saima, Wang, Yunsheng, Siddique, Muhammad Hussnain, Zubair, Errum, Hayat, Sumreen, Zubair, Muhammad, Roy, Arpita, Mumtaz, Rabia, Azeem, Muhammad, Emran, Talha Bin, Shahid, Muhammad Qasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570767/
https://www.ncbi.nlm.nih.gov/pubmed/36234800
http://dx.doi.org/10.3390/molecules27196263
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author Muzammil, Saima
Wang, Yunsheng
Siddique, Muhammad Hussnain
Zubair, Errum
Hayat, Sumreen
Zubair, Muhammad
Roy, Arpita
Mumtaz, Rabia
Azeem, Muhammad
Emran, Talha Bin
Shahid, Muhammad Qasim
author_facet Muzammil, Saima
Wang, Yunsheng
Siddique, Muhammad Hussnain
Zubair, Errum
Hayat, Sumreen
Zubair, Muhammad
Roy, Arpita
Mumtaz, Rabia
Azeem, Muhammad
Emran, Talha Bin
Shahid, Muhammad Qasim
author_sort Muzammil, Saima
collection PubMed
description Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification of bioactive compounds present in these extracts. The effects of using different solvents for the extraction of C. didymus on the contents of major polyphenols and biological activities were investigated. Plant sample was shade dried, ground to a fine powder, and then soaked in pure acetone, ethanol and methanol. The highest contents of major polyphenols were found in methanol-based extract, i.e., chlorogenic acid, HB acid, kaempferol, ferulic acid, quercetin and benzoic acid with 305.02, 12.42, 11.5, 23.33, 975.7 and 428 mg/g of dry weight, respectively, followed by ethanol- and acetone-based extracts. The methanol-based extract also resulted in the highest antioxidant activities (56.76%), whereas the highest antiproliferative (76.36) and alpha glucosidase inhabitation (96.65) were demonstrated in ethanol-based extracts. No antibacterial property of C. didymus was observed against all the tested strains of bacteria. Further studies should be focused on the identification of specific bioactive compounds responsible for pharmacological activities.
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spelling pubmed-95707672022-10-17 Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts Muzammil, Saima Wang, Yunsheng Siddique, Muhammad Hussnain Zubair, Errum Hayat, Sumreen Zubair, Muhammad Roy, Arpita Mumtaz, Rabia Azeem, Muhammad Emran, Talha Bin Shahid, Muhammad Qasim Molecules Article Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification of bioactive compounds present in these extracts. The effects of using different solvents for the extraction of C. didymus on the contents of major polyphenols and biological activities were investigated. Plant sample was shade dried, ground to a fine powder, and then soaked in pure acetone, ethanol and methanol. The highest contents of major polyphenols were found in methanol-based extract, i.e., chlorogenic acid, HB acid, kaempferol, ferulic acid, quercetin and benzoic acid with 305.02, 12.42, 11.5, 23.33, 975.7 and 428 mg/g of dry weight, respectively, followed by ethanol- and acetone-based extracts. The methanol-based extract also resulted in the highest antioxidant activities (56.76%), whereas the highest antiproliferative (76.36) and alpha glucosidase inhabitation (96.65) were demonstrated in ethanol-based extracts. No antibacterial property of C. didymus was observed against all the tested strains of bacteria. Further studies should be focused on the identification of specific bioactive compounds responsible for pharmacological activities. MDPI 2022-09-23 /pmc/articles/PMC9570767/ /pubmed/36234800 http://dx.doi.org/10.3390/molecules27196263 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Muzammil, Saima
Wang, Yunsheng
Siddique, Muhammad Hussnain
Zubair, Errum
Hayat, Sumreen
Zubair, Muhammad
Roy, Arpita
Mumtaz, Rabia
Azeem, Muhammad
Emran, Talha Bin
Shahid, Muhammad Qasim
Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
title Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
title_full Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
title_fullStr Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
title_full_unstemmed Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
title_short Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts
title_sort polyphenolic composition, antioxidant, antiproliferative and antidiabetic activities of coronopus didymus leaf extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570767/
https://www.ncbi.nlm.nih.gov/pubmed/36234800
http://dx.doi.org/10.3390/molecules27196263
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