Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex

The protein HFE (homeostatic iron regulator) is a key regulator of iron metabolism, and mutations in HFE underlie the most frequent form of hereditary haemochromatosis (HH-type I). Studies have shown that HFE interacts with transferrin receptor 1 (TFR1), a homodimeric type II transmembrane glycoprot...

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Detalles Bibliográficos
Autores principales: Goncalves Monteiro, Daniela, Rishi, Gautam, Gorman, Declan M., Burnet, Guillaume, Aliyanto, Randy, Rosengren, K. Johan, Frazer, David M., Subramaniam, V. Nathan, Clark, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570809/
https://www.ncbi.nlm.nih.gov/pubmed/36235117
http://dx.doi.org/10.3390/molecules27196581

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