The Role of FOXP3 on Tumor Metastasis and Its Interaction with Traditional Chinese Medicine

Forkhead box protein 3 (FOXP3) is an important transcription factor for regulatory T cells (Tregs) and plays an important role in their immunosuppressive function. In recent years, studies have found that FOXP3 is expressed in many kinds of tumors and plays different roles in tumors’ biological beha...

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Detalles Bibliográficos
Autores principales: Ma, Benxu, Miao, Wenjun, Xiao, Jieqiong, Chen, Xinyi, Xu, Jing, Li, Yinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570879/
https://www.ncbi.nlm.nih.gov/pubmed/36235242
http://dx.doi.org/10.3390/molecules27196706
Descripción
Sumario:Forkhead box protein 3 (FOXP3) is an important transcription factor for regulatory T cells (Tregs) and plays an important role in their immunosuppressive function. In recent years, studies have found that FOXP3 is expressed in many kinds of tumors and plays different roles in tumors’ biological behaviors, including tumor proliferation, metastasis, drug resistance, and prognosis. However, the effects of FOXP3 on tumor metastasis and its interaction with traditional Chinese medicine (TCM) remain unclear. Therefore, in this review, we focus on the effects of FOXP3 on tumor metastasis and its relationship with TCM, which can provide evidence for further research and therapy in clinical settings.

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