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Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation

An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent eva...

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Autores principales: Zardán Gómez de la Torre, Teresa, Lindmark, Tuulikki, Cheung, Ocean, Bergström, Christel, Strømme, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570901/
https://www.ncbi.nlm.nih.gov/pubmed/36234733
http://dx.doi.org/10.3390/molecules27196188
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author Zardán Gómez de la Torre, Teresa
Lindmark, Tuulikki
Cheung, Ocean
Bergström, Christel
Strømme, Maria
author_facet Zardán Gómez de la Torre, Teresa
Lindmark, Tuulikki
Cheung, Ocean
Bergström, Christel
Strømme, Maria
author_sort Zardán Gómez de la Torre, Teresa
collection PubMed
description An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent evaporation method. Crystallization of celecoxib was suppressed, and no reaction with the carrier was detected. The MMC formulation was evaluated in vitro and in vivo in terms of oral bioavailability. Celebra(®), a commercially available formulation, was used as a reference. The two celecoxib formulations were orally administrated in male rats (average of n = 6 animals per group), and blood samples for plasma were taken from all animals at different time points after administration. There was no statistical difference (p > 0.05) in AUC(inf) between the two formulations. The results showed that MMC may be a promising drug delivery excipient for increasing the bioavailability of compounds with solubility-limited absorption.
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spelling pubmed-95709012022-10-17 Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation Zardán Gómez de la Torre, Teresa Lindmark, Tuulikki Cheung, Ocean Bergström, Christel Strømme, Maria Molecules Communication An attractive approach to increase the aqueous apparent solubility of poorly soluble drugs is to formulate them in their amorphous state. In the present study, celecoxib, a poorly soluble drug, was successfully loaded into mesoporous magnesium carbonate (MMC) in its amorphous state via a solvent evaporation method. Crystallization of celecoxib was suppressed, and no reaction with the carrier was detected. The MMC formulation was evaluated in vitro and in vivo in terms of oral bioavailability. Celebra(®), a commercially available formulation, was used as a reference. The two celecoxib formulations were orally administrated in male rats (average of n = 6 animals per group), and blood samples for plasma were taken from all animals at different time points after administration. There was no statistical difference (p > 0.05) in AUC(inf) between the two formulations. The results showed that MMC may be a promising drug delivery excipient for increasing the bioavailability of compounds with solubility-limited absorption. MDPI 2022-09-21 /pmc/articles/PMC9570901/ /pubmed/36234733 http://dx.doi.org/10.3390/molecules27196188 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Zardán Gómez de la Torre, Teresa
Lindmark, Tuulikki
Cheung, Ocean
Bergström, Christel
Strømme, Maria
Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
title Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
title_full Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
title_fullStr Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
title_full_unstemmed Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
title_short Bioavailability of Celecoxib Formulated with Mesoporous Magnesium Carbonate—An In Vivo Evaluation
title_sort bioavailability of celecoxib formulated with mesoporous magnesium carbonate—an in vivo evaluation
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570901/
https://www.ncbi.nlm.nih.gov/pubmed/36234733
http://dx.doi.org/10.3390/molecules27196188
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