A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA

Thiodiglycolic acid (TDGA) is a biomarker for monitoring vinyl chloride exposure. Exploring a facile, rapid and precise analysis technology to quantify TDGA is of great significance. In this research, we demonstrate a fluorescent sensor based on dual-emissive UiO-66 for TDGA detection. This ratiomet...

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Autores principales: Fan, Yangchun, Jiang, Xin, Che, Jie, Li, Mingfeng, Zhang, Xuejuan, Gao, Daojiang, Bi, Jian, Ning, Zhanglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570906/
https://www.ncbi.nlm.nih.gov/pubmed/36235080
http://dx.doi.org/10.3390/molecules27196543
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author Fan, Yangchun
Jiang, Xin
Che, Jie
Li, Mingfeng
Zhang, Xuejuan
Gao, Daojiang
Bi, Jian
Ning, Zhanglei
author_facet Fan, Yangchun
Jiang, Xin
Che, Jie
Li, Mingfeng
Zhang, Xuejuan
Gao, Daojiang
Bi, Jian
Ning, Zhanglei
author_sort Fan, Yangchun
collection PubMed
description Thiodiglycolic acid (TDGA) is a biomarker for monitoring vinyl chloride exposure. Exploring a facile, rapid and precise analysis technology to quantify TDGA is of great significance. In this research, we demonstrate a fluorescent sensor based on dual-emissive UiO-66 for TDGA detection. This ratiometric fluorescent material named C460@Tb-UiO-66-(COOH)(2) was designed and synthesized by introducing organic dye 7-diethylamino-4-methylcoumarin (C460) and Tb(3+) into UiO-66-(COOH)(2). The as-obtained C460@Tb-UiO-66-(COOH)(2) samples showed highly selective recognition, excellent anti-interference and rapid response characteristics for the recognition of TDGA. The detection limit is 0.518 mg·mL(−1), which is much lower than the threshold of 20 mg·mL(−1) for a healthy person. In addition, the mechanism of TDGA-induced fluorescence quenching is discussed in detail. This sensor is expected to detect TDGA content in human urine.
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spelling pubmed-95709062022-10-17 A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA Fan, Yangchun Jiang, Xin Che, Jie Li, Mingfeng Zhang, Xuejuan Gao, Daojiang Bi, Jian Ning, Zhanglei Molecules Article Thiodiglycolic acid (TDGA) is a biomarker for monitoring vinyl chloride exposure. Exploring a facile, rapid and precise analysis technology to quantify TDGA is of great significance. In this research, we demonstrate a fluorescent sensor based on dual-emissive UiO-66 for TDGA detection. This ratiometric fluorescent material named C460@Tb-UiO-66-(COOH)(2) was designed and synthesized by introducing organic dye 7-diethylamino-4-methylcoumarin (C460) and Tb(3+) into UiO-66-(COOH)(2). The as-obtained C460@Tb-UiO-66-(COOH)(2) samples showed highly selective recognition, excellent anti-interference and rapid response characteristics for the recognition of TDGA. The detection limit is 0.518 mg·mL(−1), which is much lower than the threshold of 20 mg·mL(−1) for a healthy person. In addition, the mechanism of TDGA-induced fluorescence quenching is discussed in detail. This sensor is expected to detect TDGA content in human urine. MDPI 2022-10-03 /pmc/articles/PMC9570906/ /pubmed/36235080 http://dx.doi.org/10.3390/molecules27196543 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fan, Yangchun
Jiang, Xin
Che, Jie
Li, Mingfeng
Zhang, Xuejuan
Gao, Daojiang
Bi, Jian
Ning, Zhanglei
A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA
title A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA
title_full A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA
title_fullStr A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA
title_full_unstemmed A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA
title_short A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA
title_sort ratiometric fluorescent sensor based on dye/tb (iii) functionalized uio-66 for highly sensitive detection of tdga
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570906/
https://www.ncbi.nlm.nih.gov/pubmed/36235080
http://dx.doi.org/10.3390/molecules27196543
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