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Expression of p11 in Patients with Depression

(1) Background: Some studies suggest that the p11 protein, belonging to the so-called S100 family and located, i.a., in the nucleus accumbens of the brain, is responsible for the occurrence of depression. This protein is encoded by the S100A10 gene. The aim of our study was to evaluate the expressio...

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Autores principales: Gałecka, Małgorzata, Bliźniewska-Kowalska, Katarzyna, Gałecki, Piotr, Szemraj, Janusz, Orzechowska, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570916/
https://www.ncbi.nlm.nih.gov/pubmed/36233614
http://dx.doi.org/10.3390/jcm11195743
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author Gałecka, Małgorzata
Bliźniewska-Kowalska, Katarzyna
Gałecki, Piotr
Szemraj, Janusz
Orzechowska, Agata
author_facet Gałecka, Małgorzata
Bliźniewska-Kowalska, Katarzyna
Gałecki, Piotr
Szemraj, Janusz
Orzechowska, Agata
author_sort Gałecka, Małgorzata
collection PubMed
description (1) Background: Some studies suggest that the p11 protein, belonging to the so-called S100 family and located, i.a., in the nucleus accumbens of the brain, is responsible for the occurrence of depression. This protein is encoded by the S100A10 gene. The aim of our study was to evaluate the expression of the S100A10 gene at the mRNA and protein levels in patients with depressive disorders and to determine the impact of p11 in the etiopathogenesis of depression; (2) Methods: A total of 290 people (190 depressed patients, 100 healthy controls) participated in the study. Socio-demographic and clinical data were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Venous blood was collected from all participants. RT-PCR was used to evaluate gene expression at the mRNA level, while enzyme-linked immunosorbent assay (ELISA) was used to evaluate gene expression at the protein level; (3) Results: The results indicate slightly increased S100A10 gene expression (both at the protein and mRNA levels) in patients with depression, but these values do not reach statistical significance; (4) Conclusions: Due to the fact that the study was limited by the participation of patients already undergoing antidepressant treatment, its results may confirm that pharmacological treatment affecting serotonin neurotransmission is effective in upregulation of p11 in patients with depression.
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spelling pubmed-95709162022-10-17 Expression of p11 in Patients with Depression Gałecka, Małgorzata Bliźniewska-Kowalska, Katarzyna Gałecki, Piotr Szemraj, Janusz Orzechowska, Agata J Clin Med Article (1) Background: Some studies suggest that the p11 protein, belonging to the so-called S100 family and located, i.a., in the nucleus accumbens of the brain, is responsible for the occurrence of depression. This protein is encoded by the S100A10 gene. The aim of our study was to evaluate the expression of the S100A10 gene at the mRNA and protein levels in patients with depressive disorders and to determine the impact of p11 in the etiopathogenesis of depression; (2) Methods: A total of 290 people (190 depressed patients, 100 healthy controls) participated in the study. Socio-demographic and clinical data were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Venous blood was collected from all participants. RT-PCR was used to evaluate gene expression at the mRNA level, while enzyme-linked immunosorbent assay (ELISA) was used to evaluate gene expression at the protein level; (3) Results: The results indicate slightly increased S100A10 gene expression (both at the protein and mRNA levels) in patients with depression, but these values do not reach statistical significance; (4) Conclusions: Due to the fact that the study was limited by the participation of patients already undergoing antidepressant treatment, its results may confirm that pharmacological treatment affecting serotonin neurotransmission is effective in upregulation of p11 in patients with depression. MDPI 2022-09-28 /pmc/articles/PMC9570916/ /pubmed/36233614 http://dx.doi.org/10.3390/jcm11195743 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gałecka, Małgorzata
Bliźniewska-Kowalska, Katarzyna
Gałecki, Piotr
Szemraj, Janusz
Orzechowska, Agata
Expression of p11 in Patients with Depression
title Expression of p11 in Patients with Depression
title_full Expression of p11 in Patients with Depression
title_fullStr Expression of p11 in Patients with Depression
title_full_unstemmed Expression of p11 in Patients with Depression
title_short Expression of p11 in Patients with Depression
title_sort expression of p11 in patients with depression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570916/
https://www.ncbi.nlm.nih.gov/pubmed/36233614
http://dx.doi.org/10.3390/jcm11195743
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