The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis

Atopic dermatitis (AD) is a common inflammatory skin disease with a complex pathophysiology, intertwining immune dysregulation, epidermal barrier dysfunction, IgE sensitization, environmental factors and genetic predisposition. It has been recently identified that interleukins -4 and -13 play crucia...

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Autores principales: Pappa, Georgia, Sgouros, Dimitrios, Theodoropoulos, Konstantinos, Kanelleas, Antonios, Bozi, Evangelia, Gregoriou, Stamatios, Krasagakis, Konstantinos, Katoulis, Alexander C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570949/
https://www.ncbi.nlm.nih.gov/pubmed/36233501
http://dx.doi.org/10.3390/jcm11195633
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author Pappa, Georgia
Sgouros, Dimitrios
Theodoropoulos, Konstantinos
Kanelleas, Antonios
Bozi, Evangelia
Gregoriou, Stamatios
Krasagakis, Konstantinos
Katoulis, Alexander C.
author_facet Pappa, Georgia
Sgouros, Dimitrios
Theodoropoulos, Konstantinos
Kanelleas, Antonios
Bozi, Evangelia
Gregoriou, Stamatios
Krasagakis, Konstantinos
Katoulis, Alexander C.
author_sort Pappa, Georgia
collection PubMed
description Atopic dermatitis (AD) is a common inflammatory skin disease with a complex pathophysiology, intertwining immune dysregulation, epidermal barrier dysfunction, IgE sensitization, environmental factors and genetic predisposition. It has been recently identified that interleukins -4 and -13 play crucial roles in the type-2-driven inflammation that characterizes AD, contributing to its symptomatology. Novel therapeutic approaches that target Th2 cytokines and their respective pathways have been developed, aiming to optimize the treatment of AD.
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spelling pubmed-95709492022-10-17 The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis Pappa, Georgia Sgouros, Dimitrios Theodoropoulos, Konstantinos Kanelleas, Antonios Bozi, Evangelia Gregoriou, Stamatios Krasagakis, Konstantinos Katoulis, Alexander C. J Clin Med Review Atopic dermatitis (AD) is a common inflammatory skin disease with a complex pathophysiology, intertwining immune dysregulation, epidermal barrier dysfunction, IgE sensitization, environmental factors and genetic predisposition. It has been recently identified that interleukins -4 and -13 play crucial roles in the type-2-driven inflammation that characterizes AD, contributing to its symptomatology. Novel therapeutic approaches that target Th2 cytokines and their respective pathways have been developed, aiming to optimize the treatment of AD. MDPI 2022-09-24 /pmc/articles/PMC9570949/ /pubmed/36233501 http://dx.doi.org/10.3390/jcm11195633 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pappa, Georgia
Sgouros, Dimitrios
Theodoropoulos, Konstantinos
Kanelleas, Antonios
Bozi, Evangelia
Gregoriou, Stamatios
Krasagakis, Konstantinos
Katoulis, Alexander C.
The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
title The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
title_full The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
title_fullStr The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
title_full_unstemmed The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
title_short The IL-4/-13 Axis and Its Blocking in the Treatment of Atopic Dermatitis
title_sort il-4/-13 axis and its blocking in the treatment of atopic dermatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9570949/
https://www.ncbi.nlm.nih.gov/pubmed/36233501
http://dx.doi.org/10.3390/jcm11195633
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