Cargando…

Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases

Background: Hypereosinophilic syndromes (HES) are a group of relatively rare disorders in which neurological manifestations, including ischemic stroke, are common. The hypothesized pathophysiological mechanisms are hypercoagulability, cardioembolism (mainly mediated by myocardial involvement) and da...

Descripción completa

Detalles Bibliográficos
Autores principales: Cioclu, Maria Cristina, Cavallieri, Francesco, Napoli, Manuela, Moratti, Claudio, Pascarella, Rosario, Valzania, Franco, Zedde, Marialuisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571035/
https://www.ncbi.nlm.nih.gov/pubmed/36233471
http://dx.doi.org/10.3390/jcm11195595
_version_ 1784810261860843520
author Cioclu, Maria Cristina
Cavallieri, Francesco
Napoli, Manuela
Moratti, Claudio
Pascarella, Rosario
Valzania, Franco
Zedde, Marialuisa
author_facet Cioclu, Maria Cristina
Cavallieri, Francesco
Napoli, Manuela
Moratti, Claudio
Pascarella, Rosario
Valzania, Franco
Zedde, Marialuisa
author_sort Cioclu, Maria Cristina
collection PubMed
description Background: Hypereosinophilic syndromes (HES) are a group of relatively rare disorders in which neurological manifestations, including ischemic stroke, are common. The hypothesized pathophysiological mechanisms are hypercoagulability, cardioembolism (mainly mediated by myocardial involvement) and damage to the endothelium. A variable ischemic pattern has been described, including an association of territorial and border zone ischemic stroke. Methods: Three patients who presented to our department with acute stroke were selected aiming to show these three different mechanisms inferred from the stroke pattern on brain Magnetic Resonance Imaging (MRI) and to simultaneously illustrate the three main causes of HES. Results and Discussion: The first patient is a 55-year-old man with an abrupt onset of aphasia due to an acute ischemic stroke involving the left parietal lobule and the angular gyrus; recent lab test had shown hypereosinophilia. An extensive workup excluded primary and secondary causes of hypereosinophilia so a diagnosis of idiopathic hypereosinophilia was done and he was treated with high doses of steroids. The second patient had severe hypereosinophilia and developed multiple small, scattered ischemic lesions, mainly in border zone zones. The history of severe asthma and recurrent sinusitis supported the diagnosis of EGPA (Eosinophilic Granulomatosis with Polyangiitis); considering the severe clinical conditions and the presumptive role of hypereosinophilia in determining her symptoms, steroid treatment was promptly started, with good clinical response. The third patient also presented with multiple metachronous ischemic lesions, both in cortical and border zone distribution and marked eosinophilia; the diagnostic work-up found an ovarian cancer. She was treated with steroids and then underwent surgery and adjuvant chemotherapy. Conclusions: HES should be considered in stroke etiological evaluation, although it is a rare disorder, and border zones pattern without large artery steno-occlusion on neuroimaging may help to raise the suspicion in the neurovascular diagnostic pathway. A thorough research of the sources of hypereosinophilia should be performed to select the appropriate therapy.
format Online
Article
Text
id pubmed-9571035
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95710352022-10-17 Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases Cioclu, Maria Cristina Cavallieri, Francesco Napoli, Manuela Moratti, Claudio Pascarella, Rosario Valzania, Franco Zedde, Marialuisa J Clin Med Review Background: Hypereosinophilic syndromes (HES) are a group of relatively rare disorders in which neurological manifestations, including ischemic stroke, are common. The hypothesized pathophysiological mechanisms are hypercoagulability, cardioembolism (mainly mediated by myocardial involvement) and damage to the endothelium. A variable ischemic pattern has been described, including an association of territorial and border zone ischemic stroke. Methods: Three patients who presented to our department with acute stroke were selected aiming to show these three different mechanisms inferred from the stroke pattern on brain Magnetic Resonance Imaging (MRI) and to simultaneously illustrate the three main causes of HES. Results and Discussion: The first patient is a 55-year-old man with an abrupt onset of aphasia due to an acute ischemic stroke involving the left parietal lobule and the angular gyrus; recent lab test had shown hypereosinophilia. An extensive workup excluded primary and secondary causes of hypereosinophilia so a diagnosis of idiopathic hypereosinophilia was done and he was treated with high doses of steroids. The second patient had severe hypereosinophilia and developed multiple small, scattered ischemic lesions, mainly in border zone zones. The history of severe asthma and recurrent sinusitis supported the diagnosis of EGPA (Eosinophilic Granulomatosis with Polyangiitis); considering the severe clinical conditions and the presumptive role of hypereosinophilia in determining her symptoms, steroid treatment was promptly started, with good clinical response. The third patient also presented with multiple metachronous ischemic lesions, both in cortical and border zone distribution and marked eosinophilia; the diagnostic work-up found an ovarian cancer. She was treated with steroids and then underwent surgery and adjuvant chemotherapy. Conclusions: HES should be considered in stroke etiological evaluation, although it is a rare disorder, and border zones pattern without large artery steno-occlusion on neuroimaging may help to raise the suspicion in the neurovascular diagnostic pathway. A thorough research of the sources of hypereosinophilia should be performed to select the appropriate therapy. MDPI 2022-09-23 /pmc/articles/PMC9571035/ /pubmed/36233471 http://dx.doi.org/10.3390/jcm11195595 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cioclu, Maria Cristina
Cavallieri, Francesco
Napoli, Manuela
Moratti, Claudio
Pascarella, Rosario
Valzania, Franco
Zedde, Marialuisa
Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases
title Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases
title_full Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases
title_fullStr Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases
title_full_unstemmed Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases
title_short Mechanisms and Neuroimaging Patterns of Hypereosinophilia-Related Ischemic Stroke: A Narrative Review through Three Cases
title_sort mechanisms and neuroimaging patterns of hypereosinophilia-related ischemic stroke: a narrative review through three cases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571035/
https://www.ncbi.nlm.nih.gov/pubmed/36233471
http://dx.doi.org/10.3390/jcm11195595
work_keys_str_mv AT cioclumariacristina mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases
AT cavallierifrancesco mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases
AT napolimanuela mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases
AT moratticlaudio mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases
AT pascarellarosario mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases
AT valzaniafranco mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases
AT zeddemarialuisa mechanismsandneuroimagingpatternsofhypereosinophiliarelatedischemicstrokeanarrativereviewthroughthreecases