Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing N-substituted oseltamivir derivatives were designed and synthesized to target the 150-cavity of neuraminidase (NA). In NA inhibitory assays, it was found that most of the new compounds e...

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Detalles Bibliográficos
Autores principales: Jia, Ruifang, Zhang, Jiwei, Zhang, Jian, Bertagnin, Chiara, Bonomini, Anna, Guizzo, Laura, Gao, Zhen, Ji, Xiangkai, Li, Zhuo, Liu, Chuanfeng, Ju, Han, Ma, Xiuli, Loregian, Arianna, Huang, Bing, Zhan, Peng, Liu, Xinyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571049/
https://www.ncbi.nlm.nih.gov/pubmed/36234966
http://dx.doi.org/10.3390/molecules27196426

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