Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv

Detalles Bibliográficos
Autores principales: Tran, Florian, Harris, Danielle M.M., Scharmacher, Alena, Graßhoff, Hanna, Sterner, Kristina, Schinke, Susanne, Käding, Nadja, Humrich, Jens Y., Cabral-Marques, Otávio, Bernardes, Joana P., Mishra, Neha, Bahmer, Thomas, Franzenburg, Jeanette, Hoyer, Bimba F., Glück, Andreas, Guggeis, Martina, Ossysek, Alexander, Küller, Andre, Frank, Derk, Lange, Christoph, Rupp, Jan, Heyckendorf, Jan, Gaede, Karoline I., Amital, Howard, Rosenstiel, Philip, Shoenfeld, Yehuda, Halpert, Gilad, Rosenberg, Avi Z., Schulze-Forster, Kai, Heidecke, Harald, Riemekasten, Gabriela, Schreiber, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571165/
https://www.ncbi.nlm.nih.gov/pubmed/36575710
http://dx.doi.org/10.1183/23120541.00379-2022
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author Tran, Florian
Harris, Danielle M.M.
Scharmacher, Alena
Graßhoff, Hanna
Sterner, Kristina
Schinke, Susanne
Käding, Nadja
Humrich, Jens Y.
Cabral-Marques, Otávio
Bernardes, Joana P.
Mishra, Neha
Bahmer, Thomas
Franzenburg, Jeanette
Hoyer, Bimba F.
Glück, Andreas
Guggeis, Martina
Ossysek, Alexander
Küller, Andre
Frank, Derk
Lange, Christoph
Rupp, Jan
Heyckendorf, Jan
Gaede, Karoline I.
Amital, Howard
Rosenstiel, Philip
Shoenfeld, Yehuda
Halpert, Gilad
Rosenberg, Avi Z.
Schulze-Forster, Kai
Heidecke, Harald
Riemekasten, Gabriela
Schreiber, Stefan
author_facet Tran, Florian
Harris, Danielle M.M.
Scharmacher, Alena
Graßhoff, Hanna
Sterner, Kristina
Schinke, Susanne
Käding, Nadja
Humrich, Jens Y.
Cabral-Marques, Otávio
Bernardes, Joana P.
Mishra, Neha
Bahmer, Thomas
Franzenburg, Jeanette
Hoyer, Bimba F.
Glück, Andreas
Guggeis, Martina
Ossysek, Alexander
Küller, Andre
Frank, Derk
Lange, Christoph
Rupp, Jan
Heyckendorf, Jan
Gaede, Karoline I.
Amital, Howard
Rosenstiel, Philip
Shoenfeld, Yehuda
Halpert, Gilad
Rosenberg, Avi Z.
Schulze-Forster, Kai
Heidecke, Harald
Riemekasten, Gabriela
Schreiber, Stefan
author_sort Tran, Florian
collection PubMed
description In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv
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spelling pubmed-95711652022-10-19 Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19 Tran, Florian Harris, Danielle M.M. Scharmacher, Alena Graßhoff, Hanna Sterner, Kristina Schinke, Susanne Käding, Nadja Humrich, Jens Y. Cabral-Marques, Otávio Bernardes, Joana P. Mishra, Neha Bahmer, Thomas Franzenburg, Jeanette Hoyer, Bimba F. Glück, Andreas Guggeis, Martina Ossysek, Alexander Küller, Andre Frank, Derk Lange, Christoph Rupp, Jan Heyckendorf, Jan Gaede, Karoline I. Amital, Howard Rosenstiel, Philip Shoenfeld, Yehuda Halpert, Gilad Rosenberg, Avi Z. Schulze-Forster, Kai Heidecke, Harald Riemekasten, Gabriela Schreiber, Stefan ERJ Open Res Research Letters In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv European Respiratory Society 2022-12-27 /pmc/articles/PMC9571165/ /pubmed/36575710 http://dx.doi.org/10.1183/23120541.00379-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Research Letters
Tran, Florian
Harris, Danielle M.M.
Scharmacher, Alena
Graßhoff, Hanna
Sterner, Kristina
Schinke, Susanne
Käding, Nadja
Humrich, Jens Y.
Cabral-Marques, Otávio
Bernardes, Joana P.
Mishra, Neha
Bahmer, Thomas
Franzenburg, Jeanette
Hoyer, Bimba F.
Glück, Andreas
Guggeis, Martina
Ossysek, Alexander
Küller, Andre
Frank, Derk
Lange, Christoph
Rupp, Jan
Heyckendorf, Jan
Gaede, Karoline I.
Amital, Howard
Rosenstiel, Philip
Shoenfeld, Yehuda
Halpert, Gilad
Rosenberg, Avi Z.
Schulze-Forster, Kai
Heidecke, Harald
Riemekasten, Gabriela
Schreiber, Stefan
Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
title Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
title_full Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
title_fullStr Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
title_full_unstemmed Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
title_short Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
title_sort increased protease-activated receptor 1 autoantibodies are associated with severe covid-19
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571165/
https://www.ncbi.nlm.nih.gov/pubmed/36575710
http://dx.doi.org/10.1183/23120541.00379-2022
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