Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19

In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv

Detalles Bibliográficos
Autores principales: Tran, Florian, Harris, Danielle M.M., Scharmacher, Alena, Graßhoff, Hanna, Sterner, Kristina, Schinke, Susanne, Käding, Nadja, Humrich, Jens Y., Cabral-Marques, Otávio, Bernardes, Joana P., Mishra, Neha, Bahmer, Thomas, Franzenburg, Jeanette, Hoyer, Bimba F., Glück, Andreas, Guggeis, Martina, Ossysek, Alexander, Küller, Andre, Frank, Derk, Lange, Christoph, Rupp, Jan, Heyckendorf, Jan, Gaede, Karoline I., Amital, Howard, Rosenstiel, Philip, Shoenfeld, Yehuda, Halpert, Gilad, Rosenberg, Avi Z., Schulze-Forster, Kai, Heidecke, Harald, Riemekasten, Gabriela, Schreiber, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2022
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571165/
https://www.ncbi.nlm.nih.gov/pubmed/36575710
http://dx.doi.org/10.1183/23120541.00379-2022

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