Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina

Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute co...

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Autores principales: Mathew, Shintu, Zhou, Xian, Münch, Gerald, Bodkin, Francis, Wallis, Matthew, Li, Feng, Raju, Ritesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571334/
https://www.ncbi.nlm.nih.gov/pubmed/36235129
http://dx.doi.org/10.3390/molecules27196592
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author Mathew, Shintu
Zhou, Xian
Münch, Gerald
Bodkin, Francis
Wallis, Matthew
Li, Feng
Raju, Ritesh
author_facet Mathew, Shintu
Zhou, Xian
Münch, Gerald
Bodkin, Francis
Wallis, Matthew
Li, Feng
Raju, Ritesh
author_sort Mathew, Shintu
collection PubMed
description Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC(50) values of 37.58 ± 2.45 μM, 80.6 ± 5.82 μM and 125.65 ± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 ± 14.14% at a concentration of 31.85 μM.
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spelling pubmed-95713342022-10-17 Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina Mathew, Shintu Zhou, Xian Münch, Gerald Bodkin, Francis Wallis, Matthew Li, Feng Raju, Ritesh Molecules Article Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-γ-induced NO, TNF-α and IL-6 production in RAW 264.7 cells with IC(50) values of 37.58 ± 2.45 μM, 80.6 ± 5.82 μM and 125.65 ± 0.34 μM, respectively. It also inhibited NF-κB nuclear translocation by 52.93 ± 14.14% at a concentration of 31.85 μM. MDPI 2022-10-05 /pmc/articles/PMC9571334/ /pubmed/36235129 http://dx.doi.org/10.3390/molecules27196592 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mathew, Shintu
Zhou, Xian
Münch, Gerald
Bodkin, Francis
Wallis, Matthew
Li, Feng
Raju, Ritesh
Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina
title Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina
title_full Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina
title_fullStr Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina
title_full_unstemmed Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina
title_short Tristaenone A: A New Anti-Inflammatory Compound Isolated from the Australian Indigenous Plant Tristaniopsis laurina
title_sort tristaenone a: a new anti-inflammatory compound isolated from the australian indigenous plant tristaniopsis laurina
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571334/
https://www.ncbi.nlm.nih.gov/pubmed/36235129
http://dx.doi.org/10.3390/molecules27196592
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