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Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study

A few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insuranc...

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Autores principales: Kim, So Young, Yoo, Dae Myoung, Bang, Woo Jin, Choi, Hyo Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571377/
https://www.ncbi.nlm.nih.gov/pubmed/36233561
http://dx.doi.org/10.3390/jcm11195693
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author Kim, So Young
Yoo, Dae Myoung
Bang, Woo Jin
Choi, Hyo Geun
author_facet Kim, So Young
Yoo, Dae Myoung
Bang, Woo Jin
Choi, Hyo Geun
author_sort Kim, So Young
collection PubMed
description A few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insurance Service-National Health Screening Cohort in Korea. A total of 28,962 patients with urolithiasis and 115,848 control participants were selected. The previous prescription history of PPI with days of PPI prescription was collected. To calculate the odds ratios (OR) of past, current, and days of PPI use for urolithiasis, logistic regression models were used. Subgroup analyses were conducted. The urolithiasis group demonstrated a higher rate of current PPI users than the control group (60.9% vs. 43.7%). The current PPI users indicated 2.49 times higher odds for urolithiasis than no PPI users (95% confidence intervals [CI] = 2.33–2.66). A longer duration of PPI use was associated with greater odds for urolithiasis (adjusted OR = 1.65 (95% CI = 1.54–1.77) < 1.97 (95% CI = 1.84–2.11) < 2.32 (95% CI = 2.14–2.49) for 1–19 days, 30–364 days, and 365 or more days of PPI prescription). All subgroup analyses described a consistently positive association of previous PPI use with urolithiasis. Prior PPI use was related to a higher risk of urolithiasis. The relationship between previous PPI use and urolithiasis demonstrated a dose-response association.
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spelling pubmed-95713772022-10-17 Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study Kim, So Young Yoo, Dae Myoung Bang, Woo Jin Choi, Hyo Geun J Clin Med Article A few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insurance Service-National Health Screening Cohort in Korea. A total of 28,962 patients with urolithiasis and 115,848 control participants were selected. The previous prescription history of PPI with days of PPI prescription was collected. To calculate the odds ratios (OR) of past, current, and days of PPI use for urolithiasis, logistic regression models were used. Subgroup analyses were conducted. The urolithiasis group demonstrated a higher rate of current PPI users than the control group (60.9% vs. 43.7%). The current PPI users indicated 2.49 times higher odds for urolithiasis than no PPI users (95% confidence intervals [CI] = 2.33–2.66). A longer duration of PPI use was associated with greater odds for urolithiasis (adjusted OR = 1.65 (95% CI = 1.54–1.77) < 1.97 (95% CI = 1.84–2.11) < 2.32 (95% CI = 2.14–2.49) for 1–19 days, 30–364 days, and 365 or more days of PPI prescription). All subgroup analyses described a consistently positive association of previous PPI use with urolithiasis. Prior PPI use was related to a higher risk of urolithiasis. The relationship between previous PPI use and urolithiasis demonstrated a dose-response association. MDPI 2022-09-26 /pmc/articles/PMC9571377/ /pubmed/36233561 http://dx.doi.org/10.3390/jcm11195693 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, So Young
Yoo, Dae Myoung
Bang, Woo Jin
Choi, Hyo Geun
Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
title Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
title_full Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
title_fullStr Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
title_full_unstemmed Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
title_short Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study
title_sort association between urolithiasis and history proton pump inhibitor medication: a nested case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571377/
https://www.ncbi.nlm.nih.gov/pubmed/36233561
http://dx.doi.org/10.3390/jcm11195693
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