Gamma-secretase inhibitor does not induce cytotoxicity in adult T-cell leukemia cell lines despite NOTCH1 expression

BACKGROUND: Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in other malignant neoplasms. We aimed to deter...

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Detalles Bibliográficos
Autores principales: Suzuki, Shinsuke, Hourai, Sawako, Uozumi, Kimiharu, Uchida, Yuichirou, Yoshimitsu, Makoto, Miho, Hachiman, Arima, Naomichi, Ueno, Shin-ichi, Ishitsuka, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571424/
https://www.ncbi.nlm.nih.gov/pubmed/36243685
http://dx.doi.org/10.1186/s12885-022-10003-w

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