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Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications

Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the a...

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Detalles Bibliográficos
Autores principales: Lin, Fengming, Jia, Chenyang, Wu, Fu-Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571778/
https://www.ncbi.nlm.nih.gov/pubmed/36235094
http://dx.doi.org/10.3390/molecules27196557
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author Lin, Fengming
Jia, Chenyang
Wu, Fu-Gen
author_facet Lin, Fengming
Jia, Chenyang
Wu, Fu-Gen
author_sort Lin, Fengming
collection PubMed
description Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the applications of IEISAP, including the development of various bioimaging techniques, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, positron-emission tomography imaging, radiation imaging, and multimodal imaging, which are successfully leveraged in visualizing cancer tissues and cells, bacteria, and enzyme activity. We also summarize the utilization of IEISAP in disease treatments, including anticancer, antibacterial, and antiinflammation applications, among others. We present the design, action modes, structures, properties, functions, and performance of IEISAP materials, such as nanofibers, nanoparticles, nanoaggregates, and hydrogels. Finally, we conclude with an outlook towards future developments of IEISAP materials for biomedical applications. It is believed that this review may foster the future development of IEISAP with better performance in the biomedical field.
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spelling pubmed-95717782022-10-17 Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications Lin, Fengming Jia, Chenyang Wu, Fu-Gen Molecules Review Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the applications of IEISAP, including the development of various bioimaging techniques, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, positron-emission tomography imaging, radiation imaging, and multimodal imaging, which are successfully leveraged in visualizing cancer tissues and cells, bacteria, and enzyme activity. We also summarize the utilization of IEISAP in disease treatments, including anticancer, antibacterial, and antiinflammation applications, among others. We present the design, action modes, structures, properties, functions, and performance of IEISAP materials, such as nanofibers, nanoparticles, nanoaggregates, and hydrogels. Finally, we conclude with an outlook towards future developments of IEISAP materials for biomedical applications. It is believed that this review may foster the future development of IEISAP with better performance in the biomedical field. MDPI 2022-10-04 /pmc/articles/PMC9571778/ /pubmed/36235094 http://dx.doi.org/10.3390/molecules27196557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Fengming
Jia, Chenyang
Wu, Fu-Gen
Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
title Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
title_full Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
title_fullStr Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
title_full_unstemmed Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
title_short Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
title_sort intracellular enzyme-instructed self-assembly of peptides (ieisap) for biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571778/
https://www.ncbi.nlm.nih.gov/pubmed/36235094
http://dx.doi.org/10.3390/molecules27196557
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