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Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571778/ https://www.ncbi.nlm.nih.gov/pubmed/36235094 http://dx.doi.org/10.3390/molecules27196557 |
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author | Lin, Fengming Jia, Chenyang Wu, Fu-Gen |
author_facet | Lin, Fengming Jia, Chenyang Wu, Fu-Gen |
author_sort | Lin, Fengming |
collection | PubMed |
description | Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the applications of IEISAP, including the development of various bioimaging techniques, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, positron-emission tomography imaging, radiation imaging, and multimodal imaging, which are successfully leveraged in visualizing cancer tissues and cells, bacteria, and enzyme activity. We also summarize the utilization of IEISAP in disease treatments, including anticancer, antibacterial, and antiinflammation applications, among others. We present the design, action modes, structures, properties, functions, and performance of IEISAP materials, such as nanofibers, nanoparticles, nanoaggregates, and hydrogels. Finally, we conclude with an outlook towards future developments of IEISAP materials for biomedical applications. It is believed that this review may foster the future development of IEISAP with better performance in the biomedical field. |
format | Online Article Text |
id | pubmed-9571778 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95717782022-10-17 Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications Lin, Fengming Jia, Chenyang Wu, Fu-Gen Molecules Review Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully review the advances in the applications of IEISAP, including the development of various bioimaging techniques, such as fluorescence imaging, photoacoustic imaging, magnetic resonance imaging, positron-emission tomography imaging, radiation imaging, and multimodal imaging, which are successfully leveraged in visualizing cancer tissues and cells, bacteria, and enzyme activity. We also summarize the utilization of IEISAP in disease treatments, including anticancer, antibacterial, and antiinflammation applications, among others. We present the design, action modes, structures, properties, functions, and performance of IEISAP materials, such as nanofibers, nanoparticles, nanoaggregates, and hydrogels. Finally, we conclude with an outlook towards future developments of IEISAP materials for biomedical applications. It is believed that this review may foster the future development of IEISAP with better performance in the biomedical field. MDPI 2022-10-04 /pmc/articles/PMC9571778/ /pubmed/36235094 http://dx.doi.org/10.3390/molecules27196557 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lin, Fengming Jia, Chenyang Wu, Fu-Gen Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications |
title | Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications |
title_full | Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications |
title_fullStr | Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications |
title_full_unstemmed | Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications |
title_short | Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications |
title_sort | intracellular enzyme-instructed self-assembly of peptides (ieisap) for biomedical applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571778/ https://www.ncbi.nlm.nih.gov/pubmed/36235094 http://dx.doi.org/10.3390/molecules27196557 |
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