Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus

Seven new sesquiterpenes, named croargoid A–G (1–7), were isolated from the bark of Croton argyratus. Compounds 1–4 were the first examples of eudesmane sesquiterpene lactones containing C(5)-OH group. Compound 7 was a highly degraded eudesmane sesquiterpene possessing a rare eleven-carbon skeleton....

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Autores principales: Wu, Min, Ji, Kai-Long, Sun, Peng, Lu, Jian-Mei, Yue, Jia-Rui, Cao, Dong-Hua, Xiao, Chun-Fen, Xu, You-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571801/
https://www.ncbi.nlm.nih.gov/pubmed/36234934
http://dx.doi.org/10.3390/molecules27196397
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author Wu, Min
Ji, Kai-Long
Sun, Peng
Lu, Jian-Mei
Yue, Jia-Rui
Cao, Dong-Hua
Xiao, Chun-Fen
Xu, You-Kai
author_facet Wu, Min
Ji, Kai-Long
Sun, Peng
Lu, Jian-Mei
Yue, Jia-Rui
Cao, Dong-Hua
Xiao, Chun-Fen
Xu, You-Kai
author_sort Wu, Min
collection PubMed
description Seven new sesquiterpenes, named croargoid A–G (1–7), were isolated from the bark of Croton argyratus. Compounds 1–4 were the first examples of eudesmane sesquiterpene lactones containing C(5)-OH group. Compound 7 was a highly degraded eudesmane sesquiterpene possessing a rare eleven-carbon skeleton. Their structures with stereochemistry were mainly elucidated by NMR analyses in combination with MS and ECD data. Cytotoxicities and NO inhibitions of all isolates were evaluated and only compound 5 showed moderate NO inhibitory activity.
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spelling pubmed-95718012022-10-17 Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus Wu, Min Ji, Kai-Long Sun, Peng Lu, Jian-Mei Yue, Jia-Rui Cao, Dong-Hua Xiao, Chun-Fen Xu, You-Kai Molecules Article Seven new sesquiterpenes, named croargoid A–G (1–7), were isolated from the bark of Croton argyratus. Compounds 1–4 were the first examples of eudesmane sesquiterpene lactones containing C(5)-OH group. Compound 7 was a highly degraded eudesmane sesquiterpene possessing a rare eleven-carbon skeleton. Their structures with stereochemistry were mainly elucidated by NMR analyses in combination with MS and ECD data. Cytotoxicities and NO inhibitions of all isolates were evaluated and only compound 5 showed moderate NO inhibitory activity. MDPI 2022-09-27 /pmc/articles/PMC9571801/ /pubmed/36234934 http://dx.doi.org/10.3390/molecules27196397 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Min
Ji, Kai-Long
Sun, Peng
Lu, Jian-Mei
Yue, Jia-Rui
Cao, Dong-Hua
Xiao, Chun-Fen
Xu, You-Kai
Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus
title Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus
title_full Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus
title_fullStr Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus
title_full_unstemmed Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus
title_short Croargoids A–G, Eudesmane Sesquiterpenes from the Bark of Croton argyratus
title_sort croargoids a–g, eudesmane sesquiterpenes from the bark of croton argyratus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571801/
https://www.ncbi.nlm.nih.gov/pubmed/36234934
http://dx.doi.org/10.3390/molecules27196397
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