Synthesis and Structure–Activity Relationship Studies of Pyrido [1,2-e]Purine-2,4(1H,3H)-Dione Derivatives Targeting Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis

In 2002, a new class of thymidylate synthase (TS) involved in the de novo synthesis of dTMP named Flavin-Dependent Thymidylate Synthase (FDTS) encoded by the thyX gene was discovered; FDTS is present only in 30% of prokaryote pathogens and not in human pathogens, which makes it an attractive target...

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Detalles Bibliográficos
Autores principales: Biteau, Nicolas G., Roy, Vincent, Nicolas, Cyril, Becker, Hubert F., Lambry, Jean-Christophe, Myllykallio, Hannu, Agrofoglio, Luigi A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571937/
https://www.ncbi.nlm.nih.gov/pubmed/36234754
http://dx.doi.org/10.3390/molecules27196216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571937/
https://www.ncbi.nlm.nih.gov/pubmed/36234754
http://dx.doi.org/10.3390/molecules27196216

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