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Discovery of New VEGFR-2 Inhibitors: Design, Synthesis, Anti-Proliferative Evaluation, Docking, and MD Simulation Studies

Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2 inhibitors. The congeners were synthesized possessing the pharmacophoric essential features to bind correctly with the VEGFR-2 active pocket. All members were evaluated for their cytotoxic and VEGFR-2 inhibitory potentia...

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Detalles Bibliográficos
Autores principales:	Elkaeed, Eslam B., Yousef, Reda G., Khalifa, Mohamed M., Ibrahim, Albaraa, Mehany, Ahmed B. M., Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Eldehna, Wagdy M., Metwaly, Ahmed M., Eissa, Ibrahim H., El-Zahabi, Mohamed Ayman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9571953/ https://www.ncbi.nlm.nih.gov/pubmed/36234734 http://dx.doi.org/10.3390/molecules27196203

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