Cargando…
Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis
Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV, and V collagen degradation and formation, and their association with disease activity in IBD. ECM remodeling serum bio...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572110/ https://www.ncbi.nlm.nih.gov/pubmed/36233775 http://dx.doi.org/10.3390/jcm11195907 |
_version_ | 1784810531778985984 |
---|---|
author | Domislovic, Viktor Høg Mortensen, Joachim Lindholm, Majken Kaarsdal, Morten Asser Brinar, Marko Barisic, Ana Manon-Jensen, Tina Krznaric, Zeljko |
author_facet | Domislovic, Viktor Høg Mortensen, Joachim Lindholm, Majken Kaarsdal, Morten Asser Brinar, Marko Barisic, Ana Manon-Jensen, Tina Krznaric, Zeljko |
author_sort | Domislovic, Viktor |
collection | PubMed |
description | Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV, and V collagen degradation and formation, and their association with disease activity in IBD. ECM remodeling serum biomarkers were measured in 162 IBD patients, 110 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC), and in 29 healthy donors. Biomarkers of type III collagen degradation (C3M) and formation (PRO-C3), type IV collagen degradation (C4M) and formation (PRO-C4), and type V collagen formation (PRO-C5) were measured using ELISA. Inflammatory activity was assessed using endoscopic, clinical, and biochemical activity indices. The highest diagnostic value was identified in discriminating endoscopically moderate to severe disease in CD (PRO-C3, C3M/PRO-C3, and C4M with AUC of 0.70, 0.73, and 0.69, respectively) and UC (C3M, C3M/PRO-C3, and C4M with AUC of 0.86, 0.80, and 0.76, respectively). C4M and C3M/PRO-C3 in combination yielded AUC of 0.93 (0.66–0.90) in CD and 0.94 (0.65–0.99) in UC. This study confirmed that ECM remodeling reflected disease activity in CD and UC. A combination of C4M, C3M, and PRO-C3 biomarkers may potentially be considered as a biomarker differentiating moderate to severe endoscopic disease. |
format | Online Article Text |
id | pubmed-9572110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95721102022-10-17 Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis Domislovic, Viktor Høg Mortensen, Joachim Lindholm, Majken Kaarsdal, Morten Asser Brinar, Marko Barisic, Ana Manon-Jensen, Tina Krznaric, Zeljko J Clin Med Article Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV, and V collagen degradation and formation, and their association with disease activity in IBD. ECM remodeling serum biomarkers were measured in 162 IBD patients, 110 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC), and in 29 healthy donors. Biomarkers of type III collagen degradation (C3M) and formation (PRO-C3), type IV collagen degradation (C4M) and formation (PRO-C4), and type V collagen formation (PRO-C5) were measured using ELISA. Inflammatory activity was assessed using endoscopic, clinical, and biochemical activity indices. The highest diagnostic value was identified in discriminating endoscopically moderate to severe disease in CD (PRO-C3, C3M/PRO-C3, and C4M with AUC of 0.70, 0.73, and 0.69, respectively) and UC (C3M, C3M/PRO-C3, and C4M with AUC of 0.86, 0.80, and 0.76, respectively). C4M and C3M/PRO-C3 in combination yielded AUC of 0.93 (0.66–0.90) in CD and 0.94 (0.65–0.99) in UC. This study confirmed that ECM remodeling reflected disease activity in CD and UC. A combination of C4M, C3M, and PRO-C3 biomarkers may potentially be considered as a biomarker differentiating moderate to severe endoscopic disease. MDPI 2022-10-07 /pmc/articles/PMC9572110/ /pubmed/36233775 http://dx.doi.org/10.3390/jcm11195907 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Domislovic, Viktor Høg Mortensen, Joachim Lindholm, Majken Kaarsdal, Morten Asser Brinar, Marko Barisic, Ana Manon-Jensen, Tina Krznaric, Zeljko Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis |
title | Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis |
title_full | Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis |
title_fullStr | Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis |
title_full_unstemmed | Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis |
title_short | Inflammatory Biomarkers of Extracellular Matrix Remodeling and Disease Activity in Crohn’s Disease and Ulcerative Colitis |
title_sort | inflammatory biomarkers of extracellular matrix remodeling and disease activity in crohn’s disease and ulcerative colitis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572110/ https://www.ncbi.nlm.nih.gov/pubmed/36233775 http://dx.doi.org/10.3390/jcm11195907 |
work_keys_str_mv | AT domislovicviktor inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT høgmortensenjoachim inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT lindholmmajken inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT kaarsdalmortenasser inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT brinarmarko inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT barisicana inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT manonjensentina inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis AT krznariczeljko inflammatorybiomarkersofextracellularmatrixremodelinganddiseaseactivityincrohnsdiseaseandulcerativecolitis |