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Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT

Purpose: To compare the accuracy of liver fibrosis staging with MR elastography and of staging with extracellular volume fraction (fECV) analysis using contrast-enhanced CT. Methods: This retrospective study included 60 patients who underwent both MR elastography and contrast-enhanced CT before live...

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Autores principales: Yano, Keigo, Onishi, Hiromitsu, Tsuboyama, Takahiro, Nakamoto, Atsushi, Ota, Takashi, Fukui, Hideyuki, Tatsumi, Mitsuaki, Tanigaki, Takumi, Gotoh, Kunihito, Kobayashi, Shogo, Honma, Keiichiro, Eguchi, Hidetoshi, Tomiyama, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572277/
https://www.ncbi.nlm.nih.gov/pubmed/36233521
http://dx.doi.org/10.3390/jcm11195653
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author Yano, Keigo
Onishi, Hiromitsu
Tsuboyama, Takahiro
Nakamoto, Atsushi
Ota, Takashi
Fukui, Hideyuki
Tatsumi, Mitsuaki
Tanigaki, Takumi
Gotoh, Kunihito
Kobayashi, Shogo
Honma, Keiichiro
Eguchi, Hidetoshi
Tomiyama, Noriyuki
author_facet Yano, Keigo
Onishi, Hiromitsu
Tsuboyama, Takahiro
Nakamoto, Atsushi
Ota, Takashi
Fukui, Hideyuki
Tatsumi, Mitsuaki
Tanigaki, Takumi
Gotoh, Kunihito
Kobayashi, Shogo
Honma, Keiichiro
Eguchi, Hidetoshi
Tomiyama, Noriyuki
author_sort Yano, Keigo
collection PubMed
description Purpose: To compare the accuracy of liver fibrosis staging with MR elastography and of staging with extracellular volume fraction (fECV) analysis using contrast-enhanced CT. Methods: This retrospective study included 60 patients who underwent both MR elastography and contrast-enhanced CT before liver surgery between October 2013 and July 2020. Two radiologists independently measured liver stiffness of MR elastography and fECV of CT images. Accuracy for liver fibrosis staging was assessed using receiver operating characteristic (ROC) analysis. Correlations between liver stiffness or fECV and liver fibrosis were also evaluated by means of the Spearman rank correlation coefficient. Results: The areas under the ROC curves for MR elastography for each stage differentiation of ≥F1 (0.85, 0.82 for the two radiologists), ≥F2 (0.88, 0.89), ≥F3 (0.87, 0.86), and F4 (0.84, 0.83) were greater than those for fECV analysis with CT (0.64, p = 0.06, 0.69, p = 0.2; 0.62, p < 0.005, 0.63, p < 0.005; 0.62, p < 0.005, 0.62, p < 0.01; and 0.70, p = 0.08, 0.71, p = 0.2, respectively). The correlation coefficients between liver stiffness and liver fibrosis in A0 (0.67, 0.69 for the two radiologists), A1 (0.64, 0.66) and A2 group (0.58, 0.51) were significantly higher than those between fECV and liver fibrosis (0.28, 0.30; 0.27, 0.31; and 0.23, 0.07; p < 0.05 for all comparisons). Conclusion: MR elastography allows for more accurate liver fibrosis staging compared with fECV analysis with CT. In addition, MR elastography may be less affected than fECV analysis by the inflammatory condition.
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spelling pubmed-95722772022-10-17 Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT Yano, Keigo Onishi, Hiromitsu Tsuboyama, Takahiro Nakamoto, Atsushi Ota, Takashi Fukui, Hideyuki Tatsumi, Mitsuaki Tanigaki, Takumi Gotoh, Kunihito Kobayashi, Shogo Honma, Keiichiro Eguchi, Hidetoshi Tomiyama, Noriyuki J Clin Med Article Purpose: To compare the accuracy of liver fibrosis staging with MR elastography and of staging with extracellular volume fraction (fECV) analysis using contrast-enhanced CT. Methods: This retrospective study included 60 patients who underwent both MR elastography and contrast-enhanced CT before liver surgery between October 2013 and July 2020. Two radiologists independently measured liver stiffness of MR elastography and fECV of CT images. Accuracy for liver fibrosis staging was assessed using receiver operating characteristic (ROC) analysis. Correlations between liver stiffness or fECV and liver fibrosis were also evaluated by means of the Spearman rank correlation coefficient. Results: The areas under the ROC curves for MR elastography for each stage differentiation of ≥F1 (0.85, 0.82 for the two radiologists), ≥F2 (0.88, 0.89), ≥F3 (0.87, 0.86), and F4 (0.84, 0.83) were greater than those for fECV analysis with CT (0.64, p = 0.06, 0.69, p = 0.2; 0.62, p < 0.005, 0.63, p < 0.005; 0.62, p < 0.005, 0.62, p < 0.01; and 0.70, p = 0.08, 0.71, p = 0.2, respectively). The correlation coefficients between liver stiffness and liver fibrosis in A0 (0.67, 0.69 for the two radiologists), A1 (0.64, 0.66) and A2 group (0.58, 0.51) were significantly higher than those between fECV and liver fibrosis (0.28, 0.30; 0.27, 0.31; and 0.23, 0.07; p < 0.05 for all comparisons). Conclusion: MR elastography allows for more accurate liver fibrosis staging compared with fECV analysis with CT. In addition, MR elastography may be less affected than fECV analysis by the inflammatory condition. MDPI 2022-09-25 /pmc/articles/PMC9572277/ /pubmed/36233521 http://dx.doi.org/10.3390/jcm11195653 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yano, Keigo
Onishi, Hiromitsu
Tsuboyama, Takahiro
Nakamoto, Atsushi
Ota, Takashi
Fukui, Hideyuki
Tatsumi, Mitsuaki
Tanigaki, Takumi
Gotoh, Kunihito
Kobayashi, Shogo
Honma, Keiichiro
Eguchi, Hidetoshi
Tomiyama, Noriyuki
Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT
title Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT
title_full Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT
title_fullStr Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT
title_full_unstemmed Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT
title_short Noninvasive Liver Fibrosis Staging: Comparison of MR Elastography with Extracellular Volume Fraction Analysis Using Contrast-Enhanced CT
title_sort noninvasive liver fibrosis staging: comparison of mr elastography with extracellular volume fraction analysis using contrast-enhanced ct
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9572277/
https://www.ncbi.nlm.nih.gov/pubmed/36233521
http://dx.doi.org/10.3390/jcm11195653
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